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CD41标记的微小巨核细胞染色在老年贫血诊断中的应用
作者:邢颖  
单位:齐齐哈尔医学院附属第三医院
关键词:“CD41单抗”“微小巨核细胞”“SAP染色”“老年贫血”“鉴别诊断” 
分类号:
出版年·卷·期(页码):2010·29·第四期(0-)
摘要:

目的 探讨CD41标记的微小巨核细胞染色在老年贫血诊断及鉴别诊断中的意义。方法 采用瑞特-姬姆萨染色和细胞免疫化学标记CD41染色(SAP法),检测了107例60岁以上老年贫血患者的骨髓涂片中的微小巨核细胞的数量和类型。结果 瑞-姬氏染色法和CD41标记的SAP染色法巨核细胞的检出率有统计学意义(P<0.01)。不同疾病组比较,小巨核细胞阳性率MDS组最高,依次为MDS﹥ITP﹥MA﹥ACD﹥MM﹥IDA﹥RA、AA、PRCA、CAA;淋巴样小巨核细胞MDS组检出率为73.6%,其他组均未检出。结论 CD41 标记的微小巨核细胞染色可以显著提高巨核细胞检出率;且对老年贫血具有鉴别诊断价值。

[Abstract] Objective: To assess the significance of detecting the CD41 linked micromegakaryocyte staining in differential diagnosis of anemia in the elderly. Methods: Bone marrow smears from 107 patients with anemia over the age of 60 were detected by Wright-Giemsa staining and chemical marked CD41 Streptavidin-Alkaline Phosphatase (SAP) staining for the number and types of micromegakaryocytes, respectively. Results: The detection rates of megakaryocyte by the CD41 linked staining and Wright-Giemsa staining was statistically significant difference (P<0.01). Among which the group with MDS ranks the first, followed by ITP > MA > ACD > MM > IDA > RA, AA, PRCA, CAA; Detection rate of lymphoid micromegakaryocyte from the group with MDS was 73.6%, there were not observed in other groups by CD41 linked staining. Conclusions: CD41 linked micromegakaryocyte staining obviously increases the detection rates; which is valuable for differential diagnosis of anemia in the elderly.

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