[Abstract] Objective To investigate the feasibility and safety of fast track surgery pathway for esophageal tumor resections. Methods Fifty and six patients with esophageal carcinoma who underwent colorectal esophagogartrectomy were randomly divided into two groups: control group (n=27) and fast track group (n=29). The patients in control group received conventional perioperative care, while those in the FTS group underwent fast track clinical pathway. FTS included shorten preoperative fasting time, preoperative oral carbohydrate; intraoperative temperature maintenance, fluid infusion control and untraditional use of abdominal drainage; early postoperative ambulation, enteral nutrition and potent analgesia, etc. Results Compared with control group, FTS group was associated with significantly shorter postoperative hospital stay and duration of intrvenous infusion, less medical cost and earlier postoperative passage of flatus and defecation, loss of body weight in postoperative was less in FTS group (P<0.05). There was no significant difference in morbidity or mortality between the two groups. Conclusion FTS, application in esophagogartrectomy is safe and efficient, and it can shorten postoperative hospital stay, reduce medical cost and accelarate recovery of gut function.