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高血压合并2型糖尿病中老年患者颈动脉粥样硬化的相关因素分析
作者:杨利英  
单位:南京大学医院
关键词:高血压 糖尿病 血脂异常 颈动脉粥样硬化 
分类号:
出版年·卷·期(页码):2010·29·第六期(654-657)
摘要:

目的 研究中老年高血压合并2型糖尿病患者颈动脉粥样硬化的临床特征及各种危险因素的关系。方法 入选112例慢病门诊患者分为高血压组38例(EH组),糖尿病组36例(DM组),高血压合并糖尿病组38例(EH+DM组),门诊健康体检者30例作为对照组,进行颈动脉超声检测及其他生化指标检测。结果 (1)EH组、DM组、EH+DM组血浆TC、TG、LDL-C明显高于对照组,HDL-C明显低于对照组。(2)EH组、DM组、EH+DM组的颈动脉内膜中层厚度(IMT)及斑块指数明显高于对照组,以EH+DM组最高。(3)与对照组比较EH组、DM组、EH+DM组颈动脉阻力指数均增高,以EH+DM组最高。结论 高血压、糖尿病、脂代谢紊乱、肥胖、高尿酸,吸烟是动脉硬化重要危险因素,高血压合并糖尿病对动脉硬化进展有叠加作用。

Objectives: To study clinical characteristics of elderly hypertensive patients with type II diabetics and the relationship between risk factors with atherosclerosis (AS). Methods: 112 patients (pts) in outpatient were chosen and divided into 3 groups. There were 38 pts in hypertension group (EH), 36 pts in diabetic group (DM) and 38 pts in hypertension with diabetic group (EH+DM). 30 healthy people were selected as control group. Laboratory and carotid artery ultrasound testing were conducted in all subjects. Results: (1) The plasma levels of cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C) was higher in EH, DM and EH+DM groups than that of control group respectively, while the level of high density lipoprotein-cholesterol (HDL-C) was significantly lower than that of control group. (2) The intermedium thick (IMT) of carotid endarterium and plaque index in EH, DM or EH+DM groups was higher than that of control group respectively, especially was highest in EH+DM group. (3) The resistant index of carotid artery in EH, DM or EH+DM groups was higher than that of control group respectively, especially was highest in EH+DM group. Conclusion: Hypertension, diabetic, lipid metabolic disorder, obese, hyperuricemia and smoking are all important risk factors of AS. Hypertensive and diabetic status may accelerate the development of AS.

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