阿维A联合窄谱UVB照射治疗中重度寻常型斑块状银屑病疗效观察-东南大学学报医学版

阿维A联合窄谱UVB照射治疗中重度寻常型斑块状银屑病疗效观察

作者：史玉玲

单位：同济大学附属第十人民医院

分类号：

出版年·卷·期（页码）：2010·29·第六期（618-620）

摘要：

目的观察阿维A联合窄谱中波紫外线（narrow band ultraviolet B，NB-UVB）治疗中重度寻常型斑块状银屑病的临床疗效。方法将125例中重度斑块状银屑病患者随机分为A、B两组，A组单独采用NB-UVB照射治疗，B组采用NB-UVB照射联合口服阿维A治疗，疗程4周，以银屑病皮损面积和严重程度（PASI）评分评价疗效，观察治疗前后PASI评分的变化、治疗的有效率以及副反应发生情况。结果两组治疗前后的组内评分比较，差异有统计学意义（P<0.01）；口服阿维A和NB-UVB联合治疗组的有效率为88.33%，明显高于单独使用NB-UVB照射治疗组（有效率为64.62%），差异有统计学意义（P<0.01）。结论口服阿维A联合NB—UVB治疗中重度银屑病对于迅速控制病情，缩短疗程，减少副作用，具有良好的疗效。

Objective: To observe the clinical efficacy of acitretin combined with narrow-band ultraviolet in moderate to severe plaque psoriasis. Methods: 125 cases of moderate to severe plaque psoriasis were randomly divided into A, B groups, A group were treated by NB-UVB irradiation only and B group were combined with oral acitretin for 4 weeks. The efficacy of treatment was evaluated by Psoriasis Area and Severity Index (PASI), PASI scores, effective rate and the occurrence of side effects were observed before and after treatment. Results: Compared PASI scores in the group before and after treatment respectively, the difference was statistically significant (P <0.01). Effective rate was 88.33% in oral acitretin combined with NB-UVB group, significantly higher than in NB-UVB irradiation group (effective rate 64.62%), the difference was statistically significant (P <0.01).Conclusions: Oral acitretin combined with NB-UVB therapy can rapidly control the disease, shorten the course of treatment , reduce side effects .

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