【Abstract】Objective To study the relationship between lipoprotein lipase (LPL) gene Hind Ⅲ and PvuⅡpolymorphism and the preeclampsia (PE) with polymerase chain reaction (PCR) and restriction fragment length polymorphism（RFLP) from the heredity angle, screening the predisposing genes to provide a scientific support in precaution of PE. Methods LPL gene PvuⅡ and HindⅢ polymorphism were studied using PCR-RFLP in 42 PE and 50 healthy pregnant women with similar age and gestational weeks. Results Results showed that PE group has 33 women with H+H+ genotype and 6 women with H+H－and H－H－.The control group has 30 women with H+H+ genotype and 20 women with H+H－and H－H－.The PE group has 71 allele of H+ and 7 of H－,while the control group has 72 of H+ and 28 of H－. There is a statistical significance both in the distribution of genotype and allelic frequency between the PE and control group (both the P<0.05), while the PvuⅡ polymorphism between the PE and control group has no statistical significance both in distribution of genotype and allelic frequency (both the P<0.05). Conclusions LPL gene HindⅢ polymorphism has some relationship with the occurance of PE. The H+ carrier may be easier to develop to be PE patient when pregnant. While the PvuⅡ polymorphism and allele P+ has no signifigant relationship with PE.