分泌雄激素的卵巢非特异性类固醇细胞瘤1例并文献复习-东南大学学报医学版

分泌雄激素的卵巢非特异性类固醇细胞瘤1例并文献复习

单位：1. 东南大学附属中大医院妇产科, 江苏南京 210009;
2. 东南大学附属中大医院生殖医学科, 江苏南京 210009

分类号：R737.3

出版年·卷·期（页码）：2025·44·第四期（605-608）

摘要：

目的:探讨卵巢非特异性类固醇细胞瘤(steroid cell tumor, not otherwise specified, SCT-NOS)的临床病理特征、诊疗策略及预后管理。方法:回顾性分析东南大学附属中大医院收治的1例分泌雄激素的卵巢SCT-NOS患者的临床表现及诊治过程,结合文献进行复习。结果:患者为44岁女性,主诉脱发伴面部胡须9年,继发性闭经8年。实验室检查示血清总睾酮水平显著升高(11.29 ng·mL^-1,参考值<0.75 ng·mL^-1)。盆腔超声及磁共振平扫+增强显示右侧附件区占位。行全子宫及双侧附件切除术,术后病理符合SCT-NOS诊断标准:肿瘤细胞呈多角形,胞质丰富嗜酸性,免疫组化显示inhibin-α(+)、calretinin(+)、Melan-A(-),Ki-67指数2%+。术后3 d内血清睾酮水平降至0.46 ng·mL^-1,予雌激素补充治疗。结论:卵巢SCT-NOS属于罕见性索间质肿瘤,其发病机制尚未明确,特征性表现为高雄激素血症导致的男性化体征。影像学检查对良恶性鉴别价值有限,确诊依赖术后病理及免疫组化。手术治疗为首选方案,术式选择须综合评估肿瘤恶性潜能、患者年龄及生育需求。

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