血清CA199、TSGF水平与非小细胞肺癌患者预后生存的关系-东南大学学报医学版

血清CA199、TSGF水平与非小细胞肺癌患者预后生存的关系

单位：秦皇岛市第二医院肿瘤科, 河北秦皇岛 066600

关键词：非小细胞肺癌糖类抗原199 恶性肿瘤特异性生长因子贝伐珠单抗 TP化疗预后

分类号：R734.2

出版年·卷·期（页码）：2025·44·第四期（569-574）

摘要：

目的:探讨血清糖类抗原199(CA199)、恶性肿瘤特异性生长因子(TSGF)水平与非小细胞肺癌(NSCLC)患者预后生存的关系。方法:选择2019年3月至2021年3月本院收治的118例NSCLC患者,采用酶联免疫吸附法检测患者入院及3个周期治疗结束后血清CA199、TSGF水平。采用受试者工作特征(ROC)曲线评估血清CA199、TSGF水平对NSCLC患者预后的预测价值;Kaplan-Meier生存曲线分析血清CA199、TSGF表达水平与NSCLC患者预后的关系。结果:治疗后所有患者血清CA199、TSGF水平较治疗前均下降,治疗前后死亡组血清CA199、TSGF水平均高于生存组(P＜0.05)。Kaplan-Meier生存曲线显示,根据CA199、TSGF表达水平的中位数进行分组,伴有高表达CA199(≥68.22 U·mL^-1)患者3年生存率(53.33%)低于低表达CA199(＜68.22 U·mL^-1)患者(67.24%)(χ²=5.827,P=0.016);高表达TSGF(≥155.68 U·mL^-1)患者3年生存率(52.54%)低于低表达TSGF(＜155.68 U·mL^-1)患者(67.80%)(χ²=6.621,P=0.010)。CA199、TSGF联合预测NSCLC患者预后的AUC为0.867(95%CI:0.792~0.922),显著大于CA199单独预测的AUC(Z=2.402,P=0.016)及TSGF单独预测的AUC(Z=2.235,P=0.025)。结论:血清CA199、TSGF水平与贝伐珠单抗联合紫杉醇、顺铂辅助化疗方案治疗后NSCLC患者预后生存相关。

Objective: To explore the relationship between serum carbohydrate antigen 199(CA199), tumor-specific growth factor(TSGF) levels with the prognostic survival of non-small cell lung cancer(NSCLC) patients treated with bevacizumab combined with TP adjuvant chemotherapy. Methods: From March 2019 to March 2021, 118 NSCLC patients who visited our hospital were enrolled. Using enzyme-linked immunosorbent assay to detect serum CA199 and TSGF levels in patients after admission and three cycles of treatment. ROC curve was applied to evaluate the predictive value of serum CA199 and TSGF levels for the prognosis of NSCLC patients. Kaplan-Meier survival curve was used to analyze the relationship between serum CA199, TSGF expression levels with the prognosis of NSCLC. Results: After treatment, the serum levels of CA199 and TSGF in both groups decreased compared to before treatment, the serum levels of CA199 and TSGF in the death group were higher than those in the survival group before and after treatment(P<0.05). Kaplan-Meier survival curves showed that according to the median expression levels of CA199 and TSGF, patients with high CA199 expression(≥ 68.22 U·mL^-1) had a 3-year survival rate(53.33%) lower than those with low CA199 expression(<68.22 U·mL^-1)(67.24%)(χ²=5.827, P=0.016); The 3-year survival rate(52.54%) of patients with high expression of TSGF(≥ 155.68 U·mL^-1) was lower than that of patients with low expression of TSGF(<155.68 U·mL^-1)(67.80%)(χ²=6.621, P=0.010). The AUC predicted by the combination of CA199 and TSGF for the prognosis of NSCLC was 0.867(95% CI:0.792-0.922), obviously higher than the AUC predicted by CA199 alone(Z=2.402, P=0.016) and TSGF alone(Z=2.235, P=0.025). Conclusion: Serum levels of CA199 and TSGF are associated with the prognostic survival of NSCLC patients treated with bevacizumab combined with TP adjuvant chemotherapy.

参考文献：

[1] 付文慧,刘雯,黄毅力,等.中晚期非小细胞肺癌调强放疗联合化疗前后血清VEGF、CEA、NSE和CYFRA21-1的表达及其临床意义[J].现代医学,2023,51(4):501-505.
[2] BERTOLI E,DE CARLO E,BASILE D,et al.Liquid biopsy in NSCLC:an investigation with multiple clinical implications[J].Int J Mol Sci,2023,24(13):1-26.
[3] 郑波,赵红梅,郭鹏伟,等.化疗联合贝伐珠单抗靶向治疗晚期结直肠癌患者的临床效果[J].中国医药导报,2023,20(11):111-114.
[4] 陈坤燕.贝伐珠单抗联合AP方案治疗晚期非小细胞肺癌的临床效果[J].临床合理用药杂志,2024,17(31):73-76.
[5] LIU Y,LI H M,WANG R.Effectiveness and safety of adding bevacizumab to platinum-based chemotherapy as first-line treatment for advanced non-small-cell lung cancer:a meta-analysis[J].Front Med(Lausanne),2021,8(1):1-12.
[6] 黄汉琮,陈乾华,杨晓蕊.CA199、TMPRSS4在早期非小细胞肺癌组织的表达及在肿瘤血管形成中的作用[J].中国老年学杂志,2019,39(4):817-818.
[7] 王道峰,伏俊,房三友.贝伐珠单抗联合DDP化疗方案治疗非小细胞肺癌患者的疗效观察[J].实用临床医药杂志,2020,24(22):5-9.
[8] LANG D,HASLINGER W,AKBARI K,et al.Serum tumor marker dynamics as predictive biomarkers in NSCLC chemo-immunotherapy and mono-immunotherapy maintenance:a registry-based descriptive study[J].Lung Cancer(Auckl),2020,11(1):113-121.
[9] 杨波,陈洋,关静文,等.五项肿瘤标志物与非小细胞肺癌患者临床病理特征及预后的相关性研究[J].广州医科大学学报,2023,51(1):40-44.
[10] XU X,WANG W,TIAN B,et al.The predicting role of serum tumor-specific growth factor for prognosis of esophageal squamous cell carcinoma[J].BMC Cancer,2023,23(1):1067-1074.
[11] SONG X,LIANG B,WANG C,et al.Clinical value of color Doppler ultrasound combined with serum CA153,CEA and TSGF detection in the diagnosis of breast cancer[J].Exp Ther Med,2020,20(2):1822-1828.
[12] HU Q,XIAO P,LI J,et al.A retrospective analysis of serum tumor markers found in non-small cell lung cancer[J].J Cancer Res Ther,2016,12(1):117-120.
[13] 郑爽,金毅,王振.新型肿瘤标志物TSGF和Hsp90α与非小细胞肺癌的临床相关性分析[J].医学研究杂志,2019,48(6):114-117.
[14] 华红,付爱锋,戴露婵,等.血清ProGRP、TSGF与EGFR突变阳性晚期非小细胞肺癌患者疗效和预后的关系[J].现代生物医学进展,2024,24(4):701-707,712.
[15] SUN A,CHEN H,SHI X,et al.Diagnostic value of joint detection of serum TK1,TSGF,CA199,and CA724 for gastric cancer and its relationship with clinicopathologic features and prognosis[J].Am Surg,2024,12(1):97-98.

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录