呼吸道合胞病毒(RSV)是全球儿童下呼吸道感染的主要病原体之一,尤其对婴幼儿和老年人构成严重健康威胁,其致病机制尚未完全明确。蛋白质翻译后修饰是指蛋白质在翻译后发生的一系列共价修饰,这些修饰能够调控蛋白质的结构和功能,因此对多种疾病的发生和发展产生影响。近年研究表明,蛋白质翻译后修饰可能在RSV感染的过程中发挥重要作用。本文作者综述了磷酸化、泛素化、糖基化、乙酰化、棕榈酰化等常见的蛋白翻译后修饰在RSV感染中的作用机制,以期为RSV致病机制研究及RSV防治药物的研发提供新的视角。

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