N6-甲基腺嘌呤(m6A)甲基化作为真核细胞RNA表观遗传修饰的一种最常见形式,通过m6A甲基转移酶、去甲基化酶和阅读蛋白构成的动态可逆调控系统,精确介导RNA的多个代谢过程。该调控网络的异常可导致肿瘤细胞表观重塑,并通过调控肿瘤微环境、肿瘤细胞干性及血管生成,共同驱动肿瘤转移级联反应。本文作者简要介绍了m6A甲基化修饰相关酶的基本功能和调控架构,详细对其在多种恶性肿瘤转移中的调控机制进行综述,为开发基于m6A甲基化的肿瘤转移诊断标志物和精准干预策略奠定分子基础。

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