目的: 探讨血清细胞因子信号转导抑制物1(SOCS1)、粒细胞巨噬细胞集落刺激因子(GM-CSF)联合电子计算机断层扫描(CT)在肺结核诊断中的临床价值。方法: 选取156例2022年12月至2023年12月在本院接诊的疑似肺结核患者为研究对象,依据痰培养结果显示肺结核患者为疾病组(n=91),非肺结核患者为对照组(n=65)。采用ELISA法测定血清SOCS1、GM-CSF表达水平;采用ROC曲线和四格表法分析血清SOCS1、GM-CSF联合CT对肺结核的诊断价值。结果: 与对照组比较,疾病组血清SOCS1水平明显降低,血清GM-CSF水平明显升高(P＜0.05)。经CT扫描分析结果显示,疾病组扫描出空洞征、腺泡结节、磨玻璃密度影、树芽征象所占比例明显高于对照组(P＜0.05)。CT联合血清SOCS1、GM-CSF诊断肺结核的准确率为86.54%,敏感度为92.31%,特异度为78.46%。其中,三者联合诊断的准确率明显高于血清SOCS1、GM-CSF水平单独诊断及SOCS1与GM-CSF联合诊断(P＜0.05),敏感度明显高于血清GM-CSF单独诊断、CT诊断及SOCS1与GM-CSF联合诊断(P＜0.05)。结论: 肺结核患者的血清SOCS1水平明显降低、GM-CSF水平明显升高,CT联合血清SOCS1、GM-CSF对肺结核有更高的诊断价值,对临床诊断有一定应用价值。

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