ICAM-1基因多态性与结肠息肉复发的临床关系分析-东南大学学报医学版

ICAM-1基因多态性与结肠息肉复发的临床关系分析

单位：1. 秦皇岛市第一医院普通外科二病区, 河北秦皇岛 066000;
2. 秦皇岛市第一医院肿瘤科, 河北秦皇岛 066000

分类号：R574.62

出版年·卷·期（页码）：2025·44·第一期（133-138）

摘要：

目的:分析细胞间黏附分子-1(ICAM-1)基因多态性与结肠息肉复发的临床关系。方法:选取2021年1月至2022年8月本院收治的159例行内镜手术的结肠息肉患者,聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术检测患者静脉血ICAM-1基因多态性。随访1年,根据是否复发将患者分为复发组和未复发组,比较两组患者的一般资料及ICAM-1基因多态性。Logistic回归分析探讨结肠息肉患者复发的影响因素。结果:ICAM-1基因K469E多态性位点包含有2种等位基因(K、E)和3种基因型(KK、KE、EE)。随访期间,结肠息肉复发率为18.24%。复发组患者息肉直径、多发息肉占比、腺瘤性息肉占比、ICAM-1基因K等位基因频率和KK基因型占比高于未复发组(P<0.05),ICAM-1基因E等位基因频率和EE基因型占比低于未复发组(P<0.05)。多因素Logistic回归分析结果显示,息肉直径(OR=1.692,95%CI: 1.304~2.196)、多发息肉(OR=1.647,95%CI: 1.128~2.204)、腺瘤性息肉(OR=1.464,95%CI: 1.108~1.933)、ICAM-1基因型KK(OR=1.887,95%CI: 1.265~2.815)均是结肠息肉复发的影响因素(均P<0.05)。结论:结肠息肉复发患者ICAM-1基因K等位基因频率和KK基因型占比高于未复发患者,ICAM-1基因多态性是结肠息肉患者术后复发的影响因素,对结肠息肉复发有潜在的临床预测价值。

Objective: To analyze the clinical relationship between intercellular adhesion molecule-1(ICAM-1) gene polymorphism and colon polyp recurrence. Method: A total of 159 patients with colon polyps undergoing endoscopic surgery admitted to our unit from January 2021 to August 2022 were enrolled as the study objects, and the polymorphism of ICAM-1 gene was detected by polymerase chain reaction-restricted fragment length polymorphism(PCR-RFLP) technology. After 1 year of follow-up, patients were divided into recurrence group and non-recurrence group according to whether they had relapsed or not. The general information and ICAM-1 gene polymorphism of the two groups were compared. Logistic regression analysis was used to investigate the factors affecting the recurrence of colon polyps. Results: ICAM-1 gene K469E polymorphic loci contained 2 alleles(K, E) and 3 genotypes(KK, KE, EE). During the follow-up period, the recurrence rate of colon polyps was 18.24%. The polyp diameter, proportion of multiple polyps, proportion of adenomatous polyps, frequency of ICAM-1 gene K allele and proportion of KK genotype in the recurrent group were higher than those in the non-recurrent group(P<0.05). The E allele frequency and EE genotype proportion of ICAM-1 gene were lower than those of non-relapsed group(P<0.05). Polyp diameter(OR=1.692, 95%CI: 1.304-2.196), multiple polyps(OR=1.647, 95%CI: 1.128-2.204), adenomatous polyps(OR=1.464, 95%CI: 1.108-1.933) and ICAM-1 genotype KK(OR=1.887, 95%CI: 1.265-2.815) were the risk factors for postoperative recurrence in patients with colon polyps(P<0.05). Conclusion: The frequency of ICAM-1 gene K allele and the proportion of KK genotype in patients with recurrent colon polyps are higher than those in the non-recurrent group. ICAM-1 gene polymorphism, an influencing factor for postoperative recurrence in colon polyp patients, has potential clinical predictive value for colon polyp recurrence.

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