超声联合血清AKIP1、CYLD对子宫内膜癌淋巴结转移的预测价值-东南大学学报医学版

超声联合血清AKIP1、CYLD对子宫内膜癌淋巴结转移的预测价值

单位：邯郸市中心医院超声医学科, 河北邯郸 056000

分类号：R737.33;R445.1

出版年·卷·期（页码）：2024·43·第六期（939-944）

摘要：

目的:探究超声联合血清A激酶相互作用蛋白1(AKIP1)、圆柱瘤蛋白(CYLD)对子宫内膜癌淋巴结转移的预测价值。方法:选取2021年1月至2023年12月在本院确诊并进行手术的120例子宫内膜癌患者为研究对象,根据淋巴结转移状况分为未转移组74例和转移组46例。采用ELISA法检测血清AKIP1、CYLD水平。Kappa检验分析超声与病理检测淋巴结转移的一致性。绘制ROC曲线分析超声联合血清AKIP1、CYLD对子宫内膜癌淋巴结转移的预测价值。结果:两组FIGO分期、宫颈间质浸润、淋巴血管间隙浸润比较差异有统计学意义(P＜0.05)。与未转移组相比,转移组患者血清中AKIP1水平显著升高,CYLD水平显著降低(P＜0.05)。Kappa检验显示,超声与病理检测淋巴结转移的一致性较差(Kappa=0.315,P＜0.001)。与超声(Z=5.532,P＜0.001)、血清AKIP1(Z=2.396,P=0.017)、血清CYLD(Z=2.004,P=0.028)单独检测相比,超声联合血清AKIP1、CYLD对子宫内膜癌淋巴结转移预测的AUC显著升高。结论:超声联合血清AKIP1、CYLD对子宫内膜癌淋巴结转移有一定的预测价值。

Objective: To explore the predictive value of ultrasound combined with serum A kinase-interacting protein 1(AKIP1) and cylindromatosis(CYLD) in lymph node metastasis of endometrial cancer. Methods: A total of 120 patients with endometrial cancer who were diagnosed and underwent surgery in our hospital from January 2021 to December 2023 were regarded as the study subjects. They were separated into a non metastatic group of 74 cases and a metastatic group of 46 cases based on their lymph node metastasis status. ELISA method was applied to detect serum AKIP1 and CYLD levels. Kappa test was applied to analyze the consistency between ultrasound and pathological detection of lymph node metastasis. ROC curve was drawn to analyze the predictive value of ultrasound combined with serum AKIP1 and CYLD for lymph node metastasis in endometrial cancer. Results: There were obvious differences between the two groups in terms of FIGO staging, cervical stromal infiltration, and lymphatic vessel interstitial infiltration(P<0.05). Compared with the non metastatic group, the serum AKIP1 level in the metastatic group was obviously increased, while the CYLD level was obviously reduced(P<0.05). Kappa test showed poor consistency between ultrasound and pathological detection of lymph node metastasis(Kappa=0.315, P<0.001). Compared with ultrasound(Z=5.532, P<0.001), serum AKIP1(Z=2.396, P=0.017), and CYLD(Z=2.004, P=0.028) alone, ultrasound combined with serum AKIP1 and CYLD had a obviously higher AUC for predicting lymph node metastasis in endometrial cancer. Conclusion: Ultrasound combined with serum AKIP1 and CYLD has certain predictive value for lymph node metastasis in endometrial cancer.

参考文献：

[1] 刘晓凤, 綦惠娟.Ⅰ型子宫内膜癌代谢相关危险因素分析及药物治疗进展[J].妇儿健康导刊, 2023, 2(3):21-24.
[2] 樊翻, 周建政.子宫内膜癌淋巴结转移的危险因素分析[J].中国计划生育和妇产科, 2023, 15(10):28-32.
[3] 钱卫卫, 冯文.子宫内膜癌患者癌组织中核连蛋白-2表达与临床病理特征及预后的相关性分析[J].东南大学学报(医学版), 2018, 37(4):572-577.
[4] 郭聪敏, 戴一博, 耿京, 等.子宫内膜癌初始病灶大小与淋巴结转移及复发的关系[J].中华妇产科杂志, 2021, 56(4):264-270.
[5] 汪积瀛, 王若白, 李秀明.子宫内膜癌临床病理特征与盆腔淋巴结转移的影响因素分析[J].系统医学, 2023, 8(2):37-40.
[6] 樊煜欣, 余昉, 黄艳华, 等.A-激酶相互作用蛋白1作为肿瘤患者潜在预后标志物的Meta分析[J].中国医院药学杂志, 2022, 42(8):847-853.
[7] LI A, LI A, GAO X, et al.Elevated AKIP1 expression is associated with tumor invasion, shorter survival time and decreased chemosensitivity in endometrial carcinoma[J].Oncol Lett, 2022, 24(2):268-279.
[8] 朱家平, 姜祎群.CYLD基因抗肿瘤机制及其在皮肤附属器肿瘤中的研究进展[J].肿瘤综合治疗电子杂志, 2022, 8(4):6-9.
[9] LIU R, SHINRIKI S, MAESHIRO M, et al.The tumour suppressor CYLD is required for clathrin-mediated endocytosis of EGFR and cetuximab-induced apoptosis in head and neck squamous cell carcinoma[J].Cancers(Basel), 2021, 14(1):173-182.
[10] 子宫内膜癌筛查专家委员会.子宫内膜癌筛查和早期诊断专家共识(草案)[J].中国实用妇科与产科杂志, 2017, 33(10):1050-1052.
[11] 郭彬瀚, 叶萍, 陈剑, 等.基于生物信息学探究红细胞储存时间对子宫内膜癌的影响[J].临床输血与检验, 2023, 25(6):789-797.
[12] 徐水仙.宫腔镜检查在绝经后阴道流血妇女中子宫内膜癌的诊断价值分析[J].世界复合医学, 2023, 9(3):88-90.
[13] 穆瑶.子宫内膜癌病灶部位及相关病理因素与淋巴结转移部位的关系[D].郑州:郑州大学, 2023.
[14] 李巍, 杨淑丽, 苏莉, 等.不同法则评估早期子宫内膜癌淋巴结转移风险的对比研究[J].中国医刊, 2023, 58(6):675-679.
[15] 史芳.超声, MSCT对子宫内膜癌术前分期, 淋巴结转移及肌层浸润的诊断价值分析[J].中外女性健康研究, 2023, 8(16):182-184.
[16] WANG N, BAI D, KRISTIANSEN E, et al.AKIP1 promotes tumor progression by cancer-related pathways and predicts prognosis in tongue squamous cell carcinoma[J].Am J Transl Res, 2021, 13(11):12338-12351.
[17] ZHANG X, LIU S, ZHU Y.A-kinase-interacting protein 1 promotes EMT and metastasis via PI3K/Akt/IKKβ pathway in cervical cancer[J].Cell Biochem Funct, 2020, 38(6):782-791.
[18] 崔花芹.MiRNA-362-5p通过靶向NF-κB的负性调节因子CYLD对肝癌细胞恶性生物学行为的影响[D].合肥:安徽医科大学, 2013.
[19] 宋亚锋, 肖飞, 李运奇, 等.微小RNA-362-5p通过靶向调控CYLD对胃癌细胞株SGC-7901生物学行为的影响[J].中华实验外科杂志, 2018, 35(6):1055-1058.
[20] 朱绍华, 何创业, 赵芯.圆柱瘤蛋白, 白细胞介素-6, 白细胞介素-8在结直肠癌及癌前病变中的表达差异及其与患者临床病理特征的关系[J].陕西医学杂志, 2022, 51(12):1602-1606.
[21] 葛创, 钱益, 朱冬梅, 等.TRAF6基因沉默对肝癌细胞SMCC7721的影响及可能作用机制[J].海南医学院学报, 2022, 28(2):105-110.
[22] QIU C, LIU K, ZHANG S, et al.Bisdemethoxycurcumin inhibits hepatocellular carcinoma proliferation through Akt inactivation via CYLD-mediated deubiquitination[J].Drug Des Devel Ther, 2020, 5(14):993-1001.
[23] SONG H, LI D, WU T, et al.MicroRNA-301b promotes cell proliferation and apoptosis resistance in triple-negative breast cancer by targeting CYLD[J].BMB Rep, 2018, 51(11):602-607.

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