[1] XU K,WU Z,RENIER N,et al.Neural migration.Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism[J].Science,2014,344(6189):1275-1279.
[2] XIA X,HU Z,WANG S,et al.Netrin-1:an emerging player in inflammatory diseases[J].Cytokine Growth F R,2022,64:46-56.
[3] LENGRAND J,PASTUSHENKO I,VANUYTVEN S,et al.Pharmacological targeting of netrin-1 inhibits EMT in cancer[J].Nature,2023,620(7973):402-408.
[4] MÉNERET A,FRANZ E A,TROUILLARD O,et al.Mutations in the netrin-1 gene cause congenital mirror movements[J].J Clin Invest,2017,127(11):3923-3936.
[5] MENERET A,DEPIENNE C,RIANT F,et al.Congenital mirror movements:mutational analysis of RAD51 and DCC in 26 cases[J].Neurology,2014,82(22):1999-2002.
[6] BOUILLY J,MESSINA A,PAPADAKIS G,et al.DCC/NTN1 complex mutations in patients with congenital hypogonadotropic hypogonadism impair GnRH neuron development[J].Hum Mol Genet,2018,27(2):359-372.
[7] LEWIS M A,NOLAN L S,CADGE B A,et al.Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes[J].Bmc Med Genomics,2018,11(1):77.
[8] HU H,KAHRIZI K,MUSANTE L,et al.Genetics of intellectual disability in consanguineous families[J].Mol Psychiatr,2019,24(7):1027-1039.
[9] IOSSIFOV I,O'ROAK B J,SANDERS S J,et al.The contribution of de novo coding mutations to autism spectrum disorder[J].Nature,2014,515(7526):216-221.
[10] 俞柏竹,陈军磊,张振国,等.两样本孟德尔随机化分析研究肠道微生物与阿尔兹海默症之间的关系[J].现代医学,2023,51(11):1532-1539.
[11] KINNEY J W,BEMILLER S M,MURTISHAW A S,et al.Inflammation as a central mechanism in Alzheimer's disease[J].Alzheimers Dementia (N Y)2018,4(1):575-590.
[12] SWOMLEY A M,FÖRSTER S,KEENEY J T,et al.Abeta,oxidative stress in Alzheimer disease:evidence based on proteomics studies[J].Biochim Biophys Acta,2014,1842(8):1248-1257.
[13] WETZEL-SMITH M K,WETZEL-SMITH M K,HUNKAPILLER J,et al.A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death[J].Nat Med,2014,20(12):1452-1457.
[14] CHEN G,KANG S S,WANG Z,et al.Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration,promoting Alzheimer's disease pathologies[J].Sci Adv,2021,7(16):eabe4499.
[15] WIGHTMAN D P,JANSEN I E,SAVAGE J E,et al.Largest GWAS (N=1,126,563) of Alzheimer's disease implicates microglia and immune cells[J].MedRxiv,2020:2020.11.20.20235275.
[16] SPILMAN P R,CORSET V,GOROSTIZA O,et al.Netrin-1 interrupts amyloid-β amplification,increases sAβPPα in vitro and in vivo,and improves cognition in a mouse model of Alzheimer's disease[J].J Alzheimers Dis,2016,52(1):223-242.
[17] SHABANI M,HAGHANI M,TAZANGI P E,et al.Netrin-1 improves the amyloid-β-mediated suppression of memory and synaptic plasticity[J].Brain Res Bull,2017,131:107-116.
[18] ZAMANI E,PARVIZ M,ROGHANI M,et al.Netrin-1 protects the SH-SY5Y cells against amyloid beta neurotoxicity through NF-κB/Nrf2 dependent mechanism[J].Mol Biol Rep,2020,47(12):9271-9277.
[19] BOREL F,MARZOCCA F,DELCROS J G,et al.Molecular characterization of netrin-1 and APP receptor binding:new leads to block the progression of senile plaques in Alzheimer's disease[J].Biochem Bioph Res Co,2017,488(3):466-470.
[20] JU T,SUN L,FAN Y,et al.Decreased netrin-1 in mild cognitive impairment and Alzheimer's disease patients[J].Front Aging Neurosci,2022,13:762649.
[21] SUN L,JU T,WANG T,et al.Decreased netrin-1 and correlated Th17/Tregs balance disorder in Aβ1-42 induced Alzheimer's disease model rats[J].Front Aging Neurosci,2019,11:124.
[22] MENG Y,SUN S,CAO S,et al.Netrin-1:a serum marker predicting cognitive impairment after spinal cord injury[J].Dis Markers,2022,2022:1-5.
[23] SUN Y,YE L,ZHENG Y,et al.Identification of crucial genes associated with Parkinson's disease using microarray data[J].Mol Med Rep,2018,17(3):3775-3782.
[24] NEGULESCU A,MEHLEN P.Dependence receptors-the dark side awakens[J].Febs J,2018,285(21):3909-3924.
[25] JASMIN M,AHN E H,VOUTILAINEN M H,et al.Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features[J].Embo J,2021,40(3):e105537.
[26] 华烨,赵基凤,范益,等.血浆神经轴突导向因子1表达水平与帕金森病的相关性研究[J].中华老年心脑血管病杂志,2022(2):24.
[27] TORRES-BERRÍO A,HERNANDEZ G,NESTLER E J,et al.The netrin-1/DCC guidance cue pathway as a molecular target in depression:translational evidence[J].Biol Psychiat,2020,88(8):611-624.
[28] FLORES C.Role of netrin-1 in the organization and function of the mesocorticolimbic dopamine system[J].J Psychiatry Neurosci,2011,36(5):296-310.
[29] GUO D,ZHU Z,ZHONG C,et al.Increased serum Netrin-1 is associated with improved prognosis of ischemic stroke[J].Stroke,2019,50(4):845-852.
[30] LOU X,CAI Y,YANG X,et al.Serum netrin-1 concentrations are associated with clinical outcome in acute intracerebral hemorrhage[J].Clin Chim Acta,2020,508:154-160.
[31] CHEN J,YUAN D,YANG S,et al.Serum netrin-1 serves as a prognostic biomarker of aneurysmal subarachnoid hemorrhage[J].Clin Chim Acta,2019,495:294-300.
[32] XIE Y,GUO Z,CHEN F,et al.Serum netrin-1 as a potential biomarker for functional outcome of traumatic brain injury[J].Clin Chim Acta,2021,518:22-27.
[33] ZHAO Y,SONG J,DING X,et al.Detection of netrin-1 as a novel biomarker for diagnosis and chemotherapeutic monitoring of lung cancer[J].J Int Med Res,2022,50(6):030006052211053.
[34] YILDIRIM M E,KEFELI U,AYDIN D,et al.The value of plasma netrin-1 in non-small cell lung cancer patients as diagnostic and prognostic biomarker[J].Tumor Biol,2016,37(9):11903-11907.
[35] KONG C,LIU J,LIU L,et al.Interactional expression of netrin-1 and its dependence receptor UNC5B in prostate carcinoma[J].Tumor Biol,2013,34(5):2765-2772.
[36] FITAMANT J,GUENEBEAUD C,COISSIEUX M M,et al.Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer[J].P Natl Acad Sci Usa,2008,105(12):4850-4855.
[37] YIN K,WANG L,ZHANG X,et al.Netrin-1 promotes gastric cancer cell proliferation and invasion via the receptor neogenin through PI3K/AKT signaling pathway[J].Oncotarget,2017,8(31):51177-51189.
[38] GONG B,FENG Q.Netrin-1:the new tumor markers in renal clear cell carcinoma[J].Asian Pac J Trop Med,2015,8(6):489-493.
[39] CASSIER P A,NAVARIDAS R,BELLINA M,et al.Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer[J].Nature,2023,620(7973):409-416.
[40] RAMESH G,BERG A,JAYAKUMAR C.Plasma netrin-1 is a diagnostic biomarker of human cancers[J].Biomarkers,2011,16(2):172-180.
[41] PARADISI A,MAISSE C,COISSIEUX M M,et al.Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression[J].Proc Natl Acad Sci USA,2009,106(40):17146-17151.
[42] TAK E,RIDYARD D,BADULAK A,et al.Protective role for netrin-1 during diabetic nephropathy[J].J Mol Med,2013,91(9):1071-1080.
[43] GAO S,ZHANG X,QIN Y,et al.Dual actions of netrin-1 on islet insulin secretion and immune modulation[J].Clin Sci,2016,130(21):1901-1911.
[44] AY E,MARAKOG∨LU K,KIZMAZ M,et al.Evaluation of netrin-1 levels and albuminuria in patients with diabetes[J].Clin Lab Anal,2016,30(6):972-977.
[45] NEDEVA I,GATEVA A,ASSYOV Y,et al.Relationship between circulating netrin-1 levels,obesity,prediabetes and newly diagnosed type 2 diabetes[J].Arch Physiol Biochem,2022,128(6):1533-1538.
[46] BONGO J B,PENG D Q.The neuroimmune guidance cue netrin-1:a new therapeutic target in cardiovascular disease[J].J Cardiol,2014,63(2):95-98.
[47] VAN GILS J M,DERBY M C,FERNANDES L R,et al.The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques[J].Nat Immunol,2012,13(2):136-143.
[48] OKSALA N,PÄRSSINEN J,SEPPÄLÄ I,et al.Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human (s):Tampere Vascular Study (TVS)[J].Circ Cardiovasc Genet,2013,6(6):579-587.
[49] MUÑOZ J C,MARTÍN R,ALONSO C,et al.Relation between serum levels of chemotaxis-related factors and the presence of coronary artery calcification as expression of subclinical atherosclerosis[J].Clin Biochem,2017,50(18):1048-1055.
[50] SCHLEGEL M,KÖHLER D,KÖRNER A,et al.The neuroimmune guidance cue netrin-1 controls resolution programs and promotes liver regeneration[J].Hepatology,2016,63(5):1689-1705.
[51] LIU J,DU J,CHENG X,et al.Effect of Netrin-1 anti-inflammatory factor on acute lung injury in sepsis rats[J].Med Sci Monitor,2019,25:7928-7935.
[52] CHEN Z,CAO T,ZHONG X,et al.Association between serum netrin-1 levels and early neurological deterioration after acute ischemic stroke[J].Front Neurol,2022,13:953557.
[53] ZHOU Y,LIN J,PENG X,et al.The role of netrin-1 in the mouse cornea during Aspergillus fumigatus infection[J].Int Immunopharmacol,2019,71:372-381.
[54] ÇEKMEZ Y,GARIPŞ,ULUİ,et al.Maternal serum netrin-1 levels as a new biomarker of preeclampsia[J].J Matern-Fetal Neo M,2017,30(9):1072-1074.
[55] MUTLU H,AKILLI N,CANDER B,et al.Effect of serum netrin-1 levels on diagnosis and prognosis in patients admitted to the emergency service for acute coronary syndrome[J/OL].Cureus,2020,12(4):e7741.doi:10.7759/cureus.7741
[56] GUO X,DING S,LI T,et al.Macrophage-derived netrin-1 is critical for neuroangiogenesis in endometriosis[J].Inte J Biol Macromol,2020,148:226-237.
[57] 唐小波,黄更珍,张涛,等.血清netrin-1水平与急性胰腺炎严重程度的相关性及其临床应用价值[J].西部医学,2021,33(2):276-279.
[58] GUNPINAR S,MERACI B,DUNDAR N.Netrin-1 and its receptor Unc5b as markers of periodontal disease[J].J Periodontal Res,2020,55(2):267-276.
[59] KAMIANOWSKA M,SZCZEPASKI M,CHOMONTOWSKA N,et al.Is urinary netrin-1 a good marker of tubular damage in preterm newborns?[J].J Clin Med,2021,10(4):847.
[60] JIAO X,ZHANG D,HONG Q,et al.Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease[J].Front Med,2020,14(3):293-304.
[61] 黄昭前,姚红霞,林丽娥,等.Netrin-1在多发性骨髓瘤患者骨髓细胞中的表达水平和临床意义[J].临床和实验医学杂志,2017,16(21):2121-2124.
[62] 张子良,廖祥萍,黄樱.netrin-1在阿尔茨海默病中的研究进展[J].中国老年学杂志,2020,40(17):3781-3784.
[63] 陈玉,王艳琴,蔡利励,等.尿Netrin-1与NGAL联合检测在成人体外循环术后急性肾损伤早期诊断中的意义[J].实验与检验医学,2013,31(4):328-330. |