不同年龄住院T2DM患者心血管事件发生的相关因素分析-东南大学学报医学版

不同年龄住院T2DM患者心血管事件发生的相关因素分析

单位：河北省石家庄市第二医院内分泌科, 河北石家庄 050000

分类号：R587.1

出版年·卷·期（页码）：2024·43·第四期（547-552）

摘要：

目的: 探讨不同年龄段住院2型糖尿病(type 2 diabetes mellitus,T2DM)患者临床特征及心血管事件发生影响因素。方法: 收集2019年1月至12月石家庄市第二医院108例住院T2DM患者的临床资料,根据心血管事件发生分为发生组和未发生组,比较两组临床特征及不同年龄住院T2DM患者临床特征,采用Logistic回归方程分析住院T2DM患者心血管事件发生影响因素。结果: (1) 所有患者均获得2年随访结果,心血管事件发生率为37.04%;(2) 发生组年龄、T2DM病程、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、半乳糖凝集素-3(galectin-3,Gal-3)、高血压病史均大或长或高于未发生组,踝肱指数、C1q/肿瘤坏死因子相关蛋白9(C1q/tumor necrosis factor related protein 9,CTRP9)低于未发生组(P＜0.05);(3) 老年组T2DM病程、HbA1c、Gal-3、高血压病史均大或长或高于中青年组,踝肱指数、CTRP9低于中青年组(P＜0.05);(4) T2DM病程、踝肱指数、年龄、CTRP9是住院T2DM患者心血管事件发生影响因素(P＜0.05)。结论: T2DM病程、踝肱指数、年龄、CTRP9可能是导致住院T2DM患者心血管事件发生的影响因素,临床实际中应密切关注伴有上述情况的住院T2DM患者,积极防治,促进预后改善。

Objective: To explore the clinical characteristics and influencing factors of cardiovascular events in hospitalized patients with type 2 diabetes(T2DM) at different ages. Methods: The clinical data of 108 hospitalized T2DM patients in our hospital were collected from January 2019 to December 2019 for retrospective study, who were divided into occurrence group and non-occurrence group according to the occurrence of cardiovascular events to compare the clinical characteristics of the two groups and of the patients with different ages of hospitalized T2DM. The influencing factors of the occurrence of cardiovascular events of the patients with hospitalized T2DM were analyzed using Logistic regression equations. Results: (1) All patients were followed up for 2 years, and the incidence of cardiovascular events was 37.04%;(2) The age, duration of T2DM, glycosylated hemoglobin(HbA1c), galectin-3(Gal-3), and history of hypertension in the occurrence group were higher than those in the non-occurrence group, while ankle-brachial index, C1q/tumor necrosis factor related protein 9(CTRP9) was lower than that in the non-occurrence group(P<0.05);(3) The duration of T2DM, HbA1c, Gal-3, and history of hypertension in the elderly group were higher than those in the young and middle-aged group, while ankle-brachial index, CTRP9 was lower than that in the young and middle-aged group(P<0.05);(4) The duration of T2DM, ankle-brachial index, age, and CTRP9 were the factors influencing the occurrence of cardiovascular events in hospitalized T2DM patients(P<0.05). Conclusion: The duration of T2DM, ankle-brachial index, age, and CTRP9 may be the factors that influence the occurrence of cardiovascular events in hospitalized T2DM patients. In clinical practice, close attention should be paid to hospitalized T2DM patients with these conditions, and active prevention and treatment should be implemented to improve prognosis.

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