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靶向PD-1/PD-L1相关免疫治疗在HER2阳性乳腺癌中应用的研究进展
作者:丁玥1  陈金鹏1  郑士亚2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 肿瘤科, 江苏 南京 210009
关键词:程序性死亡受体1/程序性死亡受体配体1相关免疫治疗 HER2阳性乳腺癌 综述 
分类号:R737.9
出版年·卷·期(页码):2024·43·第三期(473-478)
摘要:

人表皮生长因子受体2(HER2)是一种存在于部分肿瘤细胞膜的跨膜受体蛋白,属于受体络氨酸激酶家族的一员。HER2阳性乳腺癌患者指存在HER2基因扩增或过表达的一类患者。目前在HER2阳性乳腺癌中靶向程序性死亡受体1(PD-1)或程序性死亡受体配体1(PD-L1)等免疫抑制分子治疗的效果尚不明确,本文作者围绕PD-1/PD-L1相关免疫治疗在HER2阳性乳腺癌中应用的研究进展作一综述,以期为临床HER2阳性乳腺癌的诊疗提供理论依据。

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