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我国近十年维持性血液透析患者抑郁患病率的Meta分析
作者:张沫1 2  蒋仁莲2  邵高海2  张家佳1 
单位:1. 重庆医科大学 护理学院, 重庆 400010;
2. 重庆医科大学附属永川医院 骨科创伤, 重庆 402160
关键词:维持性血液透析 抑郁 患病率 Meta分析 横断面研究 
分类号:R459.5;R749.4
出版年·卷·期(页码):2024·43·第三期(355-363)
摘要:

目的:系统评价我国近10年维持性血液透析患者抑郁的患病率。方法:计算机搜索2014年1月1日至2023年10月10日期间发表的文献,检索中国知网、万方知识服务平台、维普期刊论文数据库、中国生物医学文献数据库、美国国立图书馆(PubMed)、Web of Science、the Cochrane Library,收集有关我国维持性血液透析患者抑郁患病率的观察性研究。使用Stata 17.0软件对纳入文献进行Meta分析,采用随机效应模型和固定效应模型整合数据;通过逐一剔除每篇文献,并判断是否影响结局指标稳定性的方法进行敏感性分析;采用Egger检验结合漏斗图评价研究发表偏倚。结果:最终纳入文献25篇。Meta分析结果显示:我国近10年维持性血液透析患者抑郁的总体患病率为39.9%(95%CI:33.8%~46.0%)。亚组分析结果提示:性别、年龄、吸烟史、筛查工具、调查时间和地区等因素均会影响患者抑郁的患病率。敏感性分析表明研究结果具有稳定性;发表偏倚检测提示本研究存在发表偏倚。结论:我国近10年维持性血液透析患者抑郁的患病率为33.8%~46.0%,应加强对该组人群进行抑郁筛查,早期识别发生抑郁的危险因素,提高患者生活质量。

Objective: To assess the prevalence of depression among Chinese maintenance hemodialysis patients over the last decade. Methods:A computerized search of the literature published between January 1, 2014 and October 10, 2023 was conducted to search China Knowledge Network, Wanfang, Wipro, China Biomedical Literature Database, the U.S. National Library(PubMed), Web of Science, and the Cochrane Library, to collect observational studies on the prevalence of depression in maintenance hemodialysis patients in China. Using Stata 17.0 software, a Meta-analysis of the literature was conducted, combining the data with the random-effects and fixed-effects models. Additionally, sensitivity analysis was done by individually omitting each article and assessing its effect on the outcome indicators;the publication bias of the studies was then evaluated using Egger's test in conjunction with the funnel plot. Results:The prevalence of depression among Chinese maintenance hemodialysis patients over the past decade was found to be 39.9%(95%CI:33.8%-46.0%), as revealed by a Meta-analysis of the 25 articles finally included in this study.Subgroup analyses' findings indicated that gender, age, smoking history, assessment tools, survey duration and area could all have an impact on the prevalence of depression in those patients. An analysis of sensitivity revealed that the findings of the research were unaltered.The detection of publication bias indicated a possible bias. Conclusion:The prevalence of depression among those receiving maintenance hemodialysis has ranged from 33.8% to 46.0% in China over the past decade.Healthcare workers should strengthen depression screening for this group, identify risk factors for developing depression at an early stage, and improve patients' quality of life.

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