目的:基于丝裂原活化蛋白激酶(MAPK)信号通路相关基因(MRGs)构建预后模型,提高食管鳞状细胞癌(ESCC)患者的预后效果。方法:从癌症基因组图谱(TCGA)获取ESCC患者的相关信息,从京都基因与基因组百科全书(KEGG)数据库获取MRGs。基于MRGs中与ESCC患者生存相关基因对患者进行聚类分析,对所得差异基因进行回归分析筛选预后基因构建预后模型。对该模型划分的高低风险组进行基因本体论(GO)、KEGG分析和单样本基因富集分析(ssGSEA)。利用CellMiner数据库寻找可能与模型基因相关的药物。结果:回归分析筛选出了13个基因构建了预后模型,该模型在TCGA和基因表达综合数据库(GEO)中显示出良好预测能力。GO和KEGG分析结果显示,高低风险组白细胞介导的免疫和细胞黏附分子等生物学功能和通路具有显著差异。行ssGSEA发现,高风险组患者的免疫细胞浸润和大多数免疫功能显著强于低风险组。结论:开发了一个具有良好预测能力的预后模型,可能对ESCC的预后和治疗具有指导意义。

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