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细胞因子对前列腺癌神经内分泌分化的影响
作者:黄月婷1 2  陈南辉2 3 
单位:1. 广东医科大学 第一临床医学院, 广东 湛江 524000;
2. 梅州市人民医院 泌尿外二科, 广东 梅州 514000;
3. 广东医科大学 梅州临床医学院, 广东 梅州 514000
关键词:前列腺癌 神经内分泌分化 细胞因子 白介素 综述 
分类号:R737.25;R335
出版年·卷·期(页码):2024·43·第二期(305-309)
摘要:

前列腺癌是一种雄激素依赖性癌症,起初通过雄激素剥夺疗法(ADT)可以有效治疗,但在治疗进程中,大多数前列腺癌患者最终会出现药物耐受,逐渐发展为去势抵抗性前列腺癌。其中,神经内分泌型前列腺癌(NEPC)最难处理。随着去势治疗后癌细胞雄激素水平的降低,具有神经内分泌表型的细胞分化增加,以旁分泌的形式促进癌细胞生长。影响该机制的因素有RB1、TP53基因表达缺失,表观遗传因子变化及肿瘤微环境的改变等。在肿瘤微环境内,又以白介素-6、干扰素等细胞因子影响最大,本文作者通过阐述细胞因子在前列腺癌神经内分泌分化中作用机制的最新研究进展,以期寻找延缓NEPC进展的新策略。

参考文献:

[1] AURILIO G,CIMADAMORE A,MAZZUCCHELLI R,et al.Androgen receptor signaling pathway in prostate cancer:from genetics to clinical applications[J].Cells,2020,9(12):2653.
[2] MERSEBURGER A S,ALCARAZ A,VON KLOT C A.Androgen deprivation therapy as backbone therapy in the management of prostate cancer[J].Onco Targets Ther,2016,9:7263-7274.
[3] NIU Y,GUO C,WEN S,et al.ADT with antiandrogens in prostate cancer induces adverse effect of increasing resistance,neuroendocrine differentiation and tumor metastasis[J].Cancer Lett,2018,439:47-55.
[4] SAGNAK L,TOPALOGLU H,OZOK U,et al.Prognostic significance of neuroendocrine differentiation in prostate adenocarcinoma[J].Clin Genitourin Cancer,2011,9(2):73-80.
[5] CHEN R,DONG X,GLEAVE M.Molecular model for neuroendocrine prostate cancer progression[J].BJU Int,2018,122(4):560-570.
[6] YAMADA Y,BELTRAN H.Clinical and biological features of neuroendocrine prostate cancer[J].Curr Oncol Rep,2021,23(2):15.
[7] MEHRAJ U,GANAI R A,MACHA M A,et al.The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer:New challenges and therapeutic opportunities[J].Cell Oncol (Dordr),2021,44(6):1209-1229.
[8] ZHOU H,HE Q,LI C,et al.Focus on the tumor microenvironment:A seedbed for neuroendocrine prostate cancer[J].Front Cell Dev Biol,2022,10:955669.
[9] LIU Q,YU S,LI A,et al.Targeting interlukin-6 to relieve immunosuppression in tumor microenvironment[J].Tumour Biol,2017,39(6):1010428317712445.
[10] NATANI S,DHOPLE V M,PARVEEN A,et al.AMPK/SIRT1 signaling through p38MAPK mediates Interleukin-6 induced neuroendocrine differentiation of LNCaP prostate cancer cells[J].Biochim Biophys Acta Mol Cell Res,2021,1868(10):119085.
[11] YU S H,MAYNARD J P,VAGHASIA A M,et al.A role for paracrine interleukin-6 signaling in the tumor microenvironment in prostate tumor growth[J].Prostate,2019,79(2):215-222.
[12] JI Y,LIU B,CHEN L,et al.Repurposing ketotifen as a therapeutic strategy for neuroendocrine prostate cancer by targeting the IL-6/STAT3 pathway[J].Cell Oncol (Dordr),2023,46(5):1445-1456.
[13] ZHU Y,LIU C,CUI Y,et al.Interleukin-6 induces neuroendocrine differentiation (NED) through suppression of RE-1 silencing transcription factor (REST)[J].Prostate,2014,74(11):1086-1094.
[14] CHANG P C,WANG T Y,CHANG Y T,et al.Autophagy pathway is required for IL-6 induced neuroendocrine differentiation and chemoresistance of prostate cancer LNCaP cells[J].PLoS One,2014,9(2):e88556.
[15] LEHRER S,DIAMOND E J,MAMKINE B,et al.Serum interleukin-8 is elevated in men with prostate cancer and bone metastases[J].Technol Cancer Res Treat,2004,3(5):411.
[16] PATEL B J,PANTUCK A J,ZISMAN A,et al.CL1-GFP:an androgen independent metastatic tumor model for prostate cancer[J].J Urol,2000,164(4):1420-1425.
[17] LEE L F,LOUIE M C,DESAI S J,et al.Interleukin-8 confers androgen-independent growth and migration of LNCaP:differential effects of tyrosine kinases Src and FAK[J].Oncogene,2004,23(12):2197-2205.
[18] HUANG J,YAO J L,ZHANG L,et al.Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer[J].Am J Pathol,2005,166(6):1807-1815.
[19] LI Z,CHEN C J,WANG J K,et al.Neuroendocrine differentiation of prostate cancer[J].Asian J Androl,2013,15(3):328-332.
[20] ZHANG X Q,KONDRIKOV D,YUAN T C,et al.Receptor protein tyrosine phosphatase alpha signaling is involved in androgen depletion-induced neuroendocrine differentiation of androgen-sensitive LNCaP human prostate cancer cells[J].Oncogene,2003,22(43):6704-6716.
[21] KIM J,JIN H,ZHAO J C,et al.FOXA1 inhibits prostate cancer neuroendocrine differentiation[J].Oncogene,2017,36(28):4072-4080.
[22] DI LORENZO G,TORTORA G,D'ARMIENTO F P,et al.Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer[J].Clin Cancer Res,2002,8(11):3438-3444.
[23] LI Y,CHEN H Q,CHEN M F,et al.Neuroendocrine differentiation is involved in chemoresistance induced by EGF in prostate cancer cells[J].Life Sci,2009,84(25-26):882-887.
[24] CORTÉS M A,CARIAGA-MARTINEZ A E,LOBO M V,et al.EGF promotes neuroendocrine-like differentiation of prostate cancer cells in the presence of LY294002 through increased ErbB2 expression independent of the phosphatidylinositol 3-kinase-AKT pathway[J].Carcinogenesis,2012,33(6):1169-1177.
[25] ZHANG Y,ZHAO J,DING M,et al.Loss of exosomal miR-146a-5p from cancer-associated fibroblasts after androgen deprivation therapy contributes to prostate cancer metastasis[J].J Exp Clin Cancer Res,2020,39(1):282.
[26] PRUD'HOMME G J,KURT M,WANG Q.Pathobiology of the klotho antiaging protein and therapeutic considerations[J].Front Aging,2022,3:931331.
[27] XU X,ZHENG L,YUAN Q,et al.Transforming growth factor-β in stem cells and tissue homeostasis[J].Bone Res,2018,6:2.
[28] DICKEN H,HENSLEY P J,KYPRIANOU N.Prostate tumor neuroendocrine differentiation via EMT:the road less traveled[J].Asian J Urol,2019,6(1):82-90.
[29] NATANI S,SRUTHI K K,ASHA S M,et al.Activation of TGF-β-SMAD2 signaling by IL-6 drives neuroendocrine differentiation of prostate cancer through p38MAPK[J].Cell Signal,2022,91:110240.
[30] PLATZ E A,DE MARZO A M.Epidemiology of inflammation and prostate cancer[J].J Urol,2004,171(2 Pt 2):S36-S40.
[31] UNTERGASSER G,PLAS E,PFISTER G,et al.Interferon-gamma induces neuroendocrine-like differentiation of human prostate basal-epithelial cells[J].Prostate,2005,64(4):419-429.
[32] BORKOWETZ A,FROEHNER M,RAUNER M,et al.Neuropilin-2 is an independent prognostic factor for shorter cancer-specific survival in patients with acinar adenocarcinoma of the prostate[J].Int J Cancer,2020,146(9):2619-2627.
[33] ISLAM R,MISHRA J,POLAVARAM N S,et al.Neuropilin-2 axis in regulating secretory phenotype of neuroendocrine-like prostate cancer cells and its implication in therapy resistance[J].Cell Rep,2022,40(3):111097.
[34] WANG J,LI J,YIN L,et al.Neuropilin-2 promotes lineage plasticity and progression to neuroendocrine prostate cancer[J].Oncogene,2022,41(37):4307-4317.
[35] WANG M,WISNIEWSKI C A,XIONG C,et al.Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer[J].Sci Transl Med,2023,15(694):eade5855.

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