硫是人体内蛋白质的重要组成元素,参与机体众多代谢与催化过程,为生命所必需。近年来,随着科学家们对骨髓间充质干细胞相关研究的不断深入,含硫化合物对骨髓间充质干细胞的影响日益受到关注。含硫化合物主要包含有机硫化物、无机硫化物、天然含硫化合物以及S-非甾体抗炎药复合体等,这些化合物可能通过影响细胞信号通路、细胞周期或氧化应激反应等,调节人骨髓间充质干细胞的成骨分化能力。因此含硫化合物或许能对后续更好地利用骨髓间充质干细胞分化进行疾病治疗以及干细胞的应用提供新思路。本文作者综述了相关硫化物与骨髓间充质干细胞成骨分化的关系,并对其机制和生物学应用进行了探讨。

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