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高迁移率族蛋白B1在脓毒症作用机制中的研究进展
作者:王文博  林钰洁  马向丽  于志清  李培武 
单位:兰州大学第二医院 急诊科, 甘肃 兰州 730030
关键词:高迁移率族蛋白B1 脓毒症 免疫调控 自噬 综述 
分类号:R459.7
出版年·卷·期(页码):2024·43·第二期(271-277)
摘要:

脓毒症是一种全身性炎症反应疾病,可导致危及生命的多器官功能障碍。脓毒症的高发病率和高死亡率是重症监护领域面临的一个棘手问题,临床上目前仍以对症支持治疗为主。高迁移率族蛋白B1(HMGB1)是高迁移率族蛋白超家族成员之一,是一种含量丰富、广泛表达的核蛋白。HMGB1在脓毒症的发病过程中起着重要的作用,包括促炎、介导组织损伤、影响凝血功能、参与免疫调节等。其中,脓毒症期间免疫功能障碍是近年来重点研究方向之一。研究表明,HMGB1可通过参与天然免疫和获得性免疫的调节从而影响脓毒症的病程进展及预后。本文作者对HMGB1在脓毒症作用机制中的研究进展进行综述,以期为脓毒症的诊断和治疗提供新的靶点和思路。

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