[1] KHOSLA S,FARR J N,TCHKONIA T,et al.The role of cellular senescence in ageing and endocrine disease[J].Nat Rev Endocrinol,2020,16(5):263-275.
[2] TCHKONIA T,PALMER A K,KIRKLAND J L.New horizons:novel approaches to enhance healthspan through targeting cellular senescence and related aging mechanisms[J].J Clin Endocrinol Metab,2021,106(3):e1481-e1487.
[3] TIAN X,SELUANOV A,GORBUNOVA V.Molecular mechanisms determining lifespan in short-and long-lived species[J].Trends Endocrinol Metab,2017,28(10):722-734.
[4] YOUNG A,CASSIDY L D,NARITA M.Autophagy and senescence,converging roles in pathophysiology as seen through mouse models[J].Adv Cancer Res,2021,150:113-145.
[5] KLIONSKY D J,PETRONI G,AMARAVADI R K,et al.Autophagy in major human diseases[J].EMBO J,2021,40(19):e108863.
[6] GUERVILLE F,DE SOUTO B P,ADER I,et al.Revisiting the hallmarks of aging to identify markers of biological age[J].J Prev Alzheimers Dis,2020,7(1):56-64.
[7] 丁宇,王彦丰,左夏林,等.细胞自噬与人体衰老调控的关联性研究进展[J].国际老年医学杂志,2022,43(2):223-227.
[8] HOCKING L J,WHITEHOUSE C,HELFRICH M H.Autophagy:a new player in skeletal maintenance?[J].J Bone Miner Res,2012,27(7):1439-1447.
[9] CHEN K,YANG Y H,JIANG S D,et al.Decreased activity of osteocyte autophagy with aging may contribute to the bone loss in senile population[J].Histochem Cell Biol,2014,142(3):285-295.
[10] CAMUZARD O,SANTUCCI-DARMANIN S,BREUIL V,et al.Sex-specific autophagy modulation in osteoblastic lineage:a critical function to counteract bone loss in female[J].Oncotarget,2016,7(41):66416-66428.
[11] ONAL M,PIEMONTESE M,XIONG J,et al.Suppression of autophagy in osteocytes mimics skeletal aging[J].J Biol Chem,2013,288(24):17432-17440.
[12] XU H,XIA M,SUN L,et al.Osteocytes enhance osteogenesis by autophagy-mediated FGF23 secretion under mechanical tension[J].Front Cell Dev Biol,2021,9:782736.
[13] WEI L,CHAI S,YUE C,et al.Resveratrol protects osteocytes against oxidative stress in ovariectomized rats through AMPK/JNK1-dependent pathway leading to promotion of autophagy and inhibition of apoptosis[J].Cell Death Discov,2023,9(1):16.
[14] LUO D,REN H,LI T,et al.Rapamycin reduces severity of senile osteoporosis by activating osteocyte autophagy[J].Osteoporos Int,2016,27(3):1093-1101.
[15] FLORENCIO-SILVA R,SASSO G,SASSO-CERRI E,et al.Effects of estrogen status in osteocyte autophagy and its relation to osteocyte viability in alveolar process of ovariectomized rats[J].Biomed Pharmacother,2018,98:406-415.
[16] LAMB C A,YOSHIMORI T,TOOZE S A.The autophagosome:origins unknown,biogenesis complex[J].Nat Rev Mol Cell Biol,2013,14(12):759-774.
[17] LI D Y,YU J C,XIAO L,et al.Autophagy attenuates the oxidative stress-induced apoptosis of Mc3T3-E1 osteoblasts[J].Eur Rev Med Pharmacol Sci,2017,21(24):5548-5556.
[18] MEHRPOUR M,ESCLATINE A,BEAU I,et al.Overview of macroautophagy regulation in mammalian cells[J].Cell Res,2010,20(7):748-762.
[19] ZHANG S,XIE Y,YAN F,et al.Negative pressure wound therapy improves bone regeneration by promoting osteogenic differentiation via the AMPK-ULK1-autophagy axis[J].Autophagy,2022,18(9):2229-2245.
[20] YUE C,JIN H,ZHANG X,et al.Aucubin prevents steroid-induced osteoblast apoptosis by enhancing autophagy via AMPK activation[J].J Cell Mol Med,2021,25(21):10175-10184.
[21] WANG R,HU H,GUO J,et al.Nano-hydroxyapatite modulates osteoblast differentiation through autophagy induction via mTOR signaling pathway[J].J Biomed Nanotechnol,2019,15(2):405-415.
[22] HUANG J,YE Y,XIAO Y,et al.Geniposide ameliorates glucocorticoid-induced osteoblast apoptosis by activating autophagy[J].Biomed Pharmacother,2022,155:113829.
[23] KE D,WANG X,LIN Y,et al.Lactoferrin promotes the autophagy activity during osteoblast formation via BCL2-Beclin1 signaling[J].Mol Biol Rep,2022,49(1):259-266.
[24] PIEMONTESE M,ALMEIDA M,ROBLING A G,et al.Old age causes de novo intracortical bone remodeling and porosity in mice[J].JCI Insight,2017,2(17):e93771.
[25] MA J,DU D,LIU J,et al.Hydrogen sulphide promotes osteoclastogenesis by inhibiting autophagy through the PI3K/AKT/mTOR pathway[J].J Drug Target,2020,28(2):176-185.
[26] TONG X,GU J,SONG R,et al.Osteoprotegerin inhibit osteoclast differentiation and bone resorption by enhancing autophagy via AMPK/mTOR/p70S6K signaling pathway in vitro[J].J Cell Biochem,2019,120(2):1630-1642.
[27] TONG X,MIN W,LI S,et al.Beclin 1 positively regulates osteoprotegerin-induced inhibition of osteoclastogenesis by increasing autophagy in vitro[J].Differentiation,2021,121:35-43.
[28] FU L,WU W,SUN X,et al.Glucocorticoids enhanced osteoclast autophagy through the PI3K/Akt/mTOR signaling pathway[J].Calcif Tissue Int,2020,107(1):60-71.
[29] YANG C,TAO H,ZHANG H,et al.TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss[J].Autophagy,2022,18(12):2817-2829.
[30] ZHAN X S,EL-ASHRAM S,LUO D Z,et al.A comparative study of biological characteristics and transcriptome profiles of mesenchymal stem cells from different canine tissues[J].Int J Mol Sci,2019,20(6):1485.
[31] 邓嘉强,李韦瑶,钟丽君,等.自噬与间充质干细胞衰老的关系研究进展[J].中国生物工程杂志,2022,42(3):55-61.
[32] JONES K M,SARIC N,RUSSELL J P,et al.CHD7 maintains neural stem cell quiescence and prevents premature stem cell depletion in the adult hippocampus[J].Stem Cells,2015,33(1):196-210.
[33] FERRO F,SPELAT R,SHAW G,et al.Survival/adaptation of bone marrow-derived mesenchymal stem cells after long-term starvation through selective processes[J].Stem Cells,2019,37(6):813-827.
[34] SBRANA F V,CORTINI M,AVNET S,et al.The role of autophagy in the maintenance of stemness and differentiation of mesenchymal stem cells[J].Stem Cell Rev Rep,2016,12(6):621-633.
[35] RUBINSZTEIN D C,MARINO G,KROEMER G.Autophagy and aging[J].Cell,2011,146(5):682-695.
[36] MA Y,QI M,AN Y,et al.Autophagy controls mesenchymal stem cell properties and senescence during bone aging[J].Aging Cell,2018,17(1):e12709.
[37] QI M,ZHANG L,MA Y,et al.Autophagy maintains the function of bone marrow mesenchymal stem cells to prevent estrogen deficiency-induced osteoporosis[J].Theranostics,2017,7(18):4498-4516.
[38] LIU Z Z,HONG C G,HU W B,et al.Autophagy receptor OPTN(optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3[J].Autophagy,2021,17(10):2766-2782.
[39] ZHANG D,CHEN Y,XU X,et al.Autophagy inhibits the mesenchymal stem cell aging induced by D-galactose through ROS/JNK/p38 signalling[J].Clin Exp Pharmacol Physiol,2020,47(3):466-477.
[40] ZHENG Y,HU C J,ZHUO R H,et al.Inhibition of autophagy alleviates the senescent state of rat mesenchymal stem cells during long-term culture[J].Mol Med Rep,2014,10(6):3003-3008.
[41] CHANG T C,HSU M F,WU K K.High glucose induces bone marrow-derived mesenchymal stem cell senescence by upregulating autophagy[J].PLoS One,2015,10(5):e126537. |
