>
网站首页期刊介绍通知公告编 委 会投稿须知电子期刊广告合作联系我们
最新消息:
血管衰老影响阿尔茨海默病的研究进展
作者:葛笑1  谢春明1 2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 神经内科, 东南大学神经精神医学研究所, 江苏 南京 210009
关键词:阿尔茨海默病 痴呆 血管衰老 综述 
分类号:R741
出版年·卷·期(页码):2023·42·第五期(783-788)
摘要:

随着人口的老龄化,阿尔茨海默病(AD)患病率急剧升高,但该病目前尚无有效治疗措施。因此,寻找影响AD的高风险因素、探讨AD的发生机制、早期识别AD高危人群、寻找和发现新的干预靶点已经成为AD研究领域的热点。研究表明,早期血管衰老参与了AD的病理进程,促进细胞外β淀粉样蛋白(Aβ)异常沉积和Tau蛋白的过度磷酸化,加速AD患者脑结构改变和功能衰退,进而影响认知功能,导致痴呆等临床症状。本文作者主要围绕血管衰老与AD的关系以及血管衰老的标志物和评估方法在AD研究领域的研究进展进行综述,以期揭示血管衰老在AD病理进程中的重要意义。

参考文献:

[1] KESHAVAN A,PANNEE J,KARIKARI T K,et al.Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70[J].Brain,2021,144(2):434-449.
[2] 卜先乐,孙彬录,王延江.阿尔茨海默病防治的挑战与展望[J].中华神经科杂志,2021,54(7):635-639.
[3] 陈绍敏,王英.轻度认知功能障碍老年人阿尔茨海默病风险预测的研究进展[J].实用老年医学,2021,12(35):1304-1308.
[4] GBD 2019 Dementia Forecasting Collaborators.Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050:an analysis for the Global Burden of Disease Study 2019[J].Lancet Public Health,2022,7(2):e105-e125.
[5] DU S,LING H,GUO Z,et al.Roles of exosomal miRNA in vascular aging[J].Pharmacol Res,2021,165:105278.
[6] WANG M,KIM S H,MONTICONE R E,et al.Matrix metalloproteinases promote arterial remodeling in aging,hypertension,and atherosclerosis[J].Hypertension,2015,65(4):698-703.
[7] UNGVARI Z,TARANTINI S,SOROND F,et al.Mechanisms of vascular aging,a geroscience perspective[J].Journal of the American College of Cardiology,2020,75(8):931-941.
[8] UNGVARI Z,TARANTINI S,DONATO A J,et al.Mechanisms of vascular aging[J].Circulation Research,2018,123(7):849-867.
[9] LI X,LYU P,REN Y,et al.Arterial stiffness and cognitive impairment[J].J Neurol Sci,2017,380:1-10.
[10] SABBATINELLI J,RAMINI D,GIULIANI A,et al.Connecting vascular aging and frailty in Alzheimer's disease[J].Mech Ageing Dev,2021,195:111444.
[11] HUGHES T M,WAGENKNECHT L E,CRAFT S,et al.Arterial stiffness and dementia pathology:Atherosclerosis Risk in Communities(ARIC)-PET Study[J].Neurology,2018,90(14):e1248-e1256.
[12] TSENTIDOU G,MORAITOU D,TSOLAKI M.Cognition in vascular aging and mild cognitive impairment[J].J Alzheimers Dis,2019,72(1):55-70.
[13] BOWMAN G L,DAYON L,KIRKLAND R,et al.Blood-brain barrier breakdown,neuroinflammation,and cognitive decline in older adults[J].Alzheimers Dement,2018,14(12):1640-1650.
[14] CORTES-CANTELI M,IADECOLA C.Alzheimer's disease and vascular aging:JACC focus seminar[J].J Am Coll Cardiol,2020,75(8):942-951.
[15] GARWOOD C J,SIMPSON J E,AL M S,et al.DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression:a population-based study in the Medical Research Council Cognitive Function and Ageing Study(MRC-CFAS) cohort[J].Neuropathol Appl Neurobiol,2014,40(7):802-814.
[16] SUN R,HE T,PAN Y,et al.Effects of senescence and angiotensin Ⅱ on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells[J].Aging(Albany NY),2018,10(1):100-114.
[17] SENATOROV V J,FRIEDMAN A R,MILIKOVSKY D Z,et al.Blood-brain barrier dysfunction in aging induces hyperactivation of TGFbeta signaling and chronic yet reversible neural dysfunction[J].Sci Transl Med,2019,11(521):eaaw8283.
[18] FARACO G,PARK L,ZHOU P,et al.Hypertension enhances Abeta-induced neurovascular dysfunction,promotes beta-secretase activity,and leads to amyloidogenic processing of APP[J].J Cereb Blood Flow Metab,2016,36(1):241-252.
[19] GIULIANI A,CIRILLI I,PRATTICHIZZO F,et al.The mitomiR/Bcl-2 axis affects mitochondrial function and autophagic vacuole formation in senescent endothelial cells[J].Aging(Albany NY),2018,10(10):2855-2873.
[20] TARANTINI S,TRAN C,GORDON G R,et al.Impaired neurovascular coupling in aging and Alzheimer's disease:Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline[J].Exp Gerontol,2017,94:52-58.
[21] HURTADO-BAGES S,KNOBLOCH G,LADURNER A G,et al.The taming of PARP1 and its impact on NAD(+) metabolism[J].Mol Metab,2020,38:100950.
[22] WANG Q,ZHAO T,ZHANG W,et al.Poly(ADP-ribose) polymerase 1 mediated arginase II activation is responsible for oxidized LDL-induced endothelial dysfunction[J].Front Pharmacol,2018,9:882.
[23] TARANTINI S,YABLUCHANSKIY A,CSIPO T,et al.Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function,neurovascular coupling responses and cognitive performance in aged mice,supporting the NAD+depletion hypothesis of neurovascular aging[J].Geroscience,2019,41(5):533-542.
[24] SARLUS H,HENEKA M T.Microglia in Alzheimer's disease[J].J Clin Invest,2017,127(9):3240-3249.
[25] NORDEN D M,GODBOUT J P.Review:microglia of the aged brain:primed to be activated and resistant to regulation[J].Neuropathol Appl Neurobiol,2013,39(1):19-34.
[26] OLAH M,MENON V,HABIB N,et al.Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease[J].Nat Commun,2020,11(1):6129.
[27] OLAH M,PATRICK E,VILLANI A C,et al.A transcriptomic atlas of aged human microglia[J].Nat Commun,2018,9(1):539.
[28] DAVIES H A,MADINE J,MIDDLETON D A.Comparisons with amyloid-beta reveal an aspartate residue that stabilizes fibrils of the aortic amyloid peptide medin[J].J Biol Chem,2015,290(12):7791-7803.
[29] WAGNER J,DEGENHARDT K,VEIT M,et al.Medin co-aggregates with vascular amyloid-beta in Alzheimer's disease[J].Nature,2022,612(7938):123-131.
[30] MIGRINO R Q,KARAMANOVA N,TRURAN S,et al.Cerebrovascular medin is associated with Alzheimer's disease and vascular dementia[J].Alzheimers Dement(Amst),2020,12(1):e12072.
[31] 王琪.Fibulin-1在肾癌中的表达及相关功能的初步研究[D].武汉:华中科技大学,2013.
[32] YASMIN,MASKARI R A,MCENIERY C M,et al.The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness[J].Sci Rep,2018,8(1):8550.
[33] CHEN B,SONG L,YANG J,et al.Proteomics of serum exosomes identified fibulin-1 as a novel biomarker for mild cognitive impairment[J].Neural Regen Res,2023,18(3):587-593.
[34] 张存泰,阮磊.Fibulin-1蛋白作为血管衰老分子标志物及其应用:CN202110911507.2[P].2021-11-09.
[35] 梁小璐,晏丹,罗曼蒂,等.腓骨蛋白-1在血管平滑肌细胞衰老相关钙化中的作用及机制研究[J].中华老年医学杂志,2022(5):580-585.
[36] CHEN B,SONG L,YANG J,et al.Proteomics of serum exosomes identified fibulin-1 as a novel biomarker for mild cognitive impairment[J].Neural Regen Res,2023,18(3):587-593.
[37] 中华医学会老年医学分会心血管学组.血管衰老临床评估与干预中国专家共识(2018)[J].中华老年医学杂志,2018,37(11):1177-1184.
[38] 韩红丹,郭宏.超正常化血管衰老的研究进展[J].国际心血管病杂志,2021,48(5):274-276.
[39] ANTZA C,DOUNDOULAKIS I,AKRIVOS E,et al.Estimated arterial stiffness and prediction of vascular aging:the rising of a new era[J].Current Pharmaceutical Design,2021,27(16):1871-1877.
[40] 田新利,崔振双,施冰,等.血管健康评估及血管早衰风险预警[J].中国循证心血管医学杂志,2020,12(8):897-898.
[41] CUNHA P G,BOUTOUYRIE P,NILSSON P M,et al.Early vascular ageing(EVA):definitions and clinical applicability[J].Curr Hypertens Rev,2017,13(1):8-15.
[42] NIIRANEN T J,LYASS A,LARSON M G,et al.Prevalence,Correlates,and Prognosis of Healthy Vascular Aging in a Western Community-Dwelling Cohort:The Framingham Heart Study[J].Hypertension,2017,70(2):267-274.
[43] GREVE S V,BLICHER M K,KRUGER R,et al.Estimated carotid-femoral pulse wave velocity has similar predictive value as measured carotid-femoral pulse wave velocity[J].J Hypertens,2016,34(7):1279-1289.
[44] TAO J,LI D,DONG Y,et al.Relationship between resting heart rate and brachial-ankle pulse wave velocity in healthy Chinese population[J].Chin J Cardiovasc Dis,2014,42(8):686-692.
[45] 蔡菁菁,陆瑶.脉搏波传导速度检测用于早期血管衰老评价的中国专家共识[J].中华高血压杂志,2021,29(12):1168-1172.
[46] VAN SLOTEN T T,STEHOUWER C D.Carotid stiffness:a novel cerebrovascular disease risk factor[J].Pulse(Basel),2016,4(1):24-27.
[47] SANG Y,WU X,MIAO J,et al.Determinants of brachial-ankle pulse wave velocity and vascular aging in healthy older subjects[J].Med Sci Monit,2020,26:e923112.
[48] 徐敏,李昊,缪培智,等.经肱动脉血流介导的血管舒张功能降低在冠状动脉粥样硬化性心脏病发生中的预测价值[J].世界临床药物,2022,43(6):757-761.
[49] 毛宝玉,易艳珊,农青娇,等.肱动脉血流介导的血管舒张功能影响因素及其贡献度分析[J].广西医科大学学报,2018,35(5):729-733.
[50] 陈雅筝,李澄,朱梦颖,等.颅内动脉粥样硬化的高分辨力血管壁成像特征及临床应用[J].国际医学放射学杂志,2019,42(3):290-294.
[51] YABLUCHANSKIY A,NYUL-TOTH A,CSISZAR A,et al.Age-related alterations in the cerebrovasculature affect neurovascular coupling and BOLD fMRI responses:insights from animal models of aging[J].Psychophysiology,2021,58(7):e13718.
[52] BADJI A,SABRA D,BHERER L,et al.Arterial stiffness and brain integrity:a review of MRI findings[J].Ageing Res Rev,2019,53:100907.
[53] MAILLARD P,MITCHELL G F,HIMALI J J,et al.Aortic stiffness,increased white matter free water,and altered microstructural integrity:a continuum of injury[J].Stroke,2017,48(6):1567-1573.
[54] XU Y,ARORA R C,HIEBERT B M,et al.Non-invasive endothelial function testing and the risk of adverse outcomes:a systematic review and meta-analysis[J].Eur Heart J Cardiovasc Imaging,2014,15(7):736-746.
[55] FRESNAIS D,HUMBLE M B,BEJEROT S,et al.The association between carotid intima-media thickness and cognitive impairment:a systematic review and meta-analysis[J].Dement Geriatr Cogn Disord,2021,50(4):305-317.
[56] AFKHAMI R,WONG R,RAMADAN S,et al.Indexing cerebrovascular health using transcranialdoppler ultrasound[J].Ultrasound Med Biol,2021,47(4):919-927.
[57] VINCIGUERRA L,LANZA G,PUGLISI V,et al.Transcranial Doppler ultrasound in vascular cognitive impairment-no dementia[J].PLoS One,2019,14(4):e216162.
[58] ALWATBAN M,MURMAN D L,BASHFORD G.Cerebrovascular reactivity impairment in preclinical Alzheimer's disease[J].J Neuroimaging,2019,29(4):493-498.

服务与反馈:
文章下载】【发表评论】【查看评论】【加入收藏
提示:您还未登录,请登录!点此登录
您是第 413342 位访问者


copyright ©《东南大学学报(医学版)》编辑部
联系电话:025-83272481 83272483
电子邮件:
bjb@pub.seu.edu.cn

苏ICP备09058364