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线粒体自噬在敌草快中毒肾近曲小管损伤中保护作用的研究进展
作者:杨登会1  罗澜1  刘小露1  胡杰1  吴瑾1  赖福平1  陆安静1  喻安永1  王瑞烈1 2  陆元兰1 2 
单位:1. 遵义医科大学附属医院 急诊科, 贵州 遵义 563003;
2. 遵义医科大学附属医院 门诊部, 贵州 遵义 563003
关键词:线粒体自噬 敌草快 肾近曲小管 急性肾损伤 综述 
分类号:R595.4;R692.6
出版年·卷·期(页码):2023·42·第五期(778-782)
摘要:

随着敌草快(DQ)在我国农业的广泛应用,主动或被动接触DQ中毒的患者逐年增多。因尚无特效解毒剂,重症DQ中毒患者,尤其是并发急性肾损伤(AKI)/急性肾衰竭(ARF)者病死率较高。肾脏为DQ中毒损伤的靶器官,研究发现,线粒体在DQ中毒肾损伤中发挥重要作用:一方面,DQ中毒后诱导氧化应激使活性氧(ROS)过量产生,致使线粒体损伤,导致肾近曲小管凋亡;另一方面,DQ中毒后氧化应激诱导线粒体膜去极化,激活了自我防御机制-线粒体自噬以清除受损线粒体,最终起到保护肾脏的作用。本文作者将对线粒体自噬在DQ中毒致肾近曲小管损伤中的保护作用予以综述,以期进一步阐明DQ中毒急性肾损伤机制,为临床DQ中毒AKI治疗提供新方向。

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