目的:探讨红细胞特征参数和线粒体DNA在肺癌诊断中的应用价值。方法:随机选取2022年1月至12月南京鼓楼医院胸外科收治的肺癌患者和良性肺结节患者抗凝血。采用全自动血细胞分析仪对红细胞相关特征参数进行检测,统计分析红细胞特征参数与肺癌的相关性。另收集分离5例良性肺结节患者、5例早期肺癌患者和5例晚期肺癌患者空腹状态下的红细胞,提取DNA后通过定量PCR检测红细胞内线粒体DNA含量。结果:红细胞特征参数(包括红细胞计数、血红蛋白、红细胞平均体积、红细胞压积、红细胞分布宽度)在肺癌患者和良性肺结节患者中差异无统计学意义(P＞0.05),且基本都在正常值之内。然而,在早期肺癌患者和晚期肺癌患者中,红细胞计数和红细胞压积差异有统计学意义(P＜0.05),晚期肺癌患者红细胞线粒体DNA含量显著上升。结论:肺部良性结节患者和肺癌患者的红细胞特征参数没有差异,而在晚期肺癌患者中红细胞计数和红细胞压积下降、红细胞内线粒体DNA含量上升,它们可以作为肺癌进展的指标。

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