Objective: To analyze the expression of kallikrein 4(KLK4) and matrix antigen 2(STAG2) in cervical cancer and their relationship with clinicopathological characteristics and prognosis. Methods: A total of 397 patients with cervical cancer who were collected in our hospital from February 2015 to March 2017 were regarded as the study objects. During the operation, cancer tissues and normal tissues adjacent to cancer were collected. KLK4 mRNA and STAG2 mRNA levels and expression of KLK4 and STAG2 proteins were detected; the correlation between KLK4 and STAG2 mRNA levels was determined; Kaplan-Meier method was used to draw the survival curve of cervical cancer patients; the prognostic factors of cervical cancer patients were analyzed. Results: The levels of KLK4 mRNA and STAG2 mRNA in cervical cancer tissues were higher than those in normal adjacent tissues(P<0.05), there was a positive correlation between the two mRNA levels(r=0.461,P<0.05). The positive rates of KLK4 protein and STAG2 protein in cervical cancer tissues were higher than those in normal adjacent tissues(P<0.05). The proportions of KLK4 positive expression and STAG2 positive expression in cervical cancer patients with tumor diameter >5.0 cm, FIGO stage Ⅲ+Ⅳ, and muscle invasion depth>1/2 were higher than those with tumor diameter ≤5.0 cm, FIGO stage Ⅰ+Ⅱ, and muscle invasion depth ≤1/2(P<0.05). The survival rate of KLK4 negative group was higher than that of KLK4 positive group(P=0.002), the survival rate of STAG2 negative group was higher than that of STAG2 positive group(P<0.001). KLK4 positive expression, STAG2 positive expression, FIGO stage(Ⅲ-Ⅳ), and depth of muscle invasion(>1/2) were independent risk factors for poor prognosis of cervical cancer patients(P<0.05). Conclusion: KLK4 and STAG2 mRNA levels and protein positive expression rates in cervical cancer tissues are obviously higher than those in adjacent tissues, and they are closely related to tumor diameter, FIGO stage, depth of muscle invasion and prognosis. |
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