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Ⅰ型心肾综合征的研究进展
作者:阮亮1  乔勇2  汤成春2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 心内科, 江苏 南京 210009
关键词:Ⅰ型心肾综合征 急性心功能不全 急性肾损伤 综述 
分类号:R541; R692
出版年·卷·期(页码):2023·42·第三期(481-486)
摘要:

Ⅰ型心肾综合征(CRS-Ⅰ)是心肾综合征的一个重要亚型,指的是急性心功能不全继发急性肾损伤,常发生于急性失代偿性心力衰竭、急性冠脉综合征、心源性休克、心脏手术之后。CRS-Ⅰ通常会导致患者住院时间延长、再入院率增加及死亡率升高。由于心肾间存在多条相互作用的病理生理通路,CRS-Ⅰ的机制复杂且尚不明确,可能与血流动力学失衡、神经体液调节网络激活、炎症与氧化应激等相关。目前尚无有效的CRS-Ⅰ治疗方案,缺乏高质量循证证据及指南。本文作者就目前CRS-Ⅰ的定义、流行病学、危险因素、风险评分、病理生理机制、分子标志物以及防治作一综述。

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