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巨噬细胞的胞葬作用与炎症性疾病关系的研究进展
作者:耿锐1 2  陆军1 2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 关节与运动医学中心, 江苏 南京 210009
关键词:胞葬作用 凋亡细胞 巨噬细胞 炎症性疾病 综述 
分类号:R499; R87; R68
出版年·卷·期(页码):2023·42·第三期(466-474)
摘要:

适当终止炎症反应的放大可防止无菌性炎症、微生物炎症导致的不必要的组织损伤,对治疗炎症性疾病、恢复组织动态平衡和正常功能至关重要。胞葬作用特指在凋亡细胞发生进一步坏死、释放有毒物质,并引起炎症反应之前被以巨噬细胞为代表的吞噬细胞清除的过程。近年来的研究提示调控胞葬作用对炎症微环境具有深远的影响,因此,深入了解这两者之间的关系对于发展炎症性疾病的诊疗措施具有较大的意义。本文作者着重对胞葬作用和炎症反应进行综述,以期为基础科研和临床应用提供一定的参考。

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