[1] CRAIG J P,NICHOLS K K,AKPEK E K,et al.TFOS DEWS II definition and classification report[J].Ocul Surf,2017,15(3):276-283.
[2] STAPLETON F,ALVES M,BUNYA V Y,et al.TFOS DEWS II epidemiology report[J].Ocul Surf,2017,15(3):334-365.
[3] ZHANG S,HONG J.Risk Factors for Dry Eye in Mainland China:A Multi-Center Cross-Sectional Hospital-Based Study[J].Ophthalmic Epidemiol,2019,26(6):393-399.
[4] GALOR A.How depression might relate to dry eye disease[J].JAMA Ophthalmol,2022,140(4):399-400.
[5] BRON A J,DE PAIVA C S,CHAUHAN S K,et al.TFOS DEWS II pathophysiology report[J].Ocul Surf,2017,15(3):438-510.
[6] BOYA P,ESTEBAN-MARTÍNEZ L,SERRANO-PUEBLA A,et al.Autophagy in the eye:development,degeneration,and aging[J].Prog Retin Eye Res,2016,55:206-245.
[7] MIZUSHIMA N,OHSUMI Y,YOSHIMORI T.Autophagosome formation in mammalian cells[J].Cell Struct Funct,2002,27(6):421-429.
[8] SKEIE J M,NISHIMURA D Y,WANG C L,et al.Mitophagy:an emerging target in ocular pathology[J].Invest Ophthalmol Vis Sci,2021,62(3):22.
[9] DENTON D,KUMAR S.Autophagy-dependent cell death[J].Cell Death Differ,2019,26(4):605-616.
[10] LIN T,FILEK R,WANG J M,et al.Impression cytology implicates cell autophagy in aqueous deficiency dry eye[J].Clinical Ophthalmology,2017,11:773-779.
[11] BYUN Y S,LEE H J,SHIN S,et al.Tear ATG5 as a potential novel biomarker in the diagnosis of sjögren syndrome[J].Diagnostics(Basel),2021,11(1):71.
[12] GIPSON I K.The ocular surface:the challenge to enable and protect vision:the Friedenwald lecture[J].Invest Ophthalmol Vis Sci,2007,48(10):1-8.
[13] GEORGIEV G A,GH M S,ROMANO J,et al.Lacritin proteoforms prevent tear film collapse and maintain epithelial homeostasis[J].J Biol Chem,2021,296:100070.
[14] DIAS-TEIXEIRA K,HORTON X,MCKOWN R,et al.The lacritin-syndecan-1-heparanase axis in dry eye disease[J].Adv Exp Med Biol,2020,1221:747-757.
[15] SRINIVASAN S,THANGAVELU M,ZHANG L,et al.iTRAQ quantitative proteomics in the analysis of tears in dry eye patients[J].Invest Ophthalmol Vis Sci,2012,53(8):5052-5059.
[16] WANG N,ZIMMERMAN K,RAAB R W,et al.Lacritin rescues stressed epithelia via rapid forkhead box O3(FOXO3)-associated autophagy that restores metabolism[J].J Biol Chem,2013,288(25):18146-18161.
[17] ROLANDO M,BARABINO S.The subtle role of para-inflammation in modulating the progression of dry eye disease[J].Ocul Immunol Inflamm,2021,29(4):811-816.
[18] STUARD W,ROBERTSON D.IGFBP-3 mediates mitochondrial homeostasis during hyperosmolar stress[J].Invest Ophthalmol Vis Sci,2021,62(7):11.
[19] STUARD W L,TITONE R,ROBERTSON D M.IGFBP-3 functions as a molecular switch that mediates mitochondrial and metabolic homeostasis[J].Faseb J,2022,36(1):e22062.
[20] YU L,YU C,DONG H,et al.Recent developments about the pathogenesis of dry eye disease:based on immune inflammatory mechanisms[J].Front Pharmacol,2021,12:732887.
[21] ZHONG Z,SANCHEZ-LOPEZ E,KARIN M.Autophagy,inflammation,and immunity:a troika governing cancer and its treatment[J].Cell,2016,166(2):288-298.
[22] LIU Z,CHEN D,CHEN X,et al.Autophagy activation protects ocular surface from inflammation in a dry eye model in vitro[J].Int J Mol Sci,2020,21(23):8966.
[23] MA S,YU Z,FENG S,et al.Corneal autophagy and ocular surface inflammation:a new perspective in dry eye[J].Experimental Eye Research,2019,184:126-134.
[24] ZOUKHRI D,MACARI E,KUBLIN C L.A single injection of interleukin-1 induces reversible aqueous-tear deficiency,lacrimal gland inflammation,and acinar and ductal cell proliferation[J].Exp Eye Res,2007,84(5):894-904.
[25] ZOUKHRI D,FIX A,ALROY J,et al.Mechanisms of murine lacrimal gland repair after experimentally induced inflammation[J].Invest Ophthalmol Vis Sci,2008,49(10):4399-4406.
[26] SEO Y,JI Y W,LEE S M,et al.Activation of HIF-1α(hypoxia inducible factor-1α) prevents dry eye-induced acinar cell death in the lacrimal gland[J].Cell Death Dis,2014,5(6):e1309.
[27] DOGRU M,KOJIMA T,SIMSEK C,et al.Potential role of oxidative stress in ocular surface inflammation and dry eye disease[J].Invest Ophthalmol Vis Sci,2018,59(14):Des163-168.
[28] DENG R,HUA X,LI J,et al.Oxidative stress markers induced by hyperosmolarity in primary human corneal epithelial cells[J].PLoS One,2015,10(5):e0126561.
[29] CHEN Y,LI M,LI B,et al.Effect of reactive oxygen species generation in rabbit corneal epithelial cells on inflammatory and apoptotic signaling pathways in the presence of high osmotic pressure[J].PLoS One,2013,8(8):e72900.
[30] YIN Y,ZONG R,BAO X,et al.Oxidative stress suppresses cellular autophagy in corneal epithelium[J].Invest Ophthalmol Vis Sci,2018,59(8):3286-3293.
[31] MIAO Q,XU Y,ZHANg H,et al.Cigarette smoke induces ROS mediated autophagy impairment in human corneal epithelial cells[J].Environ Pollut,2019,245:389-397.
[32] WANG B,PENG L,OUYANG H,et al.Induction of DDIT4 Impairs autophagy through oxidative stress in dry eye[J].Invest Ophthalmol Vis Sci,2019,60(8):2836-2847.
[33] IMADA T,NAKAMURA S,HISAMURA R,et al.Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor[J].Sci Rep,2017,7(1):6965.
[34] CHHADVA P,GOLDHARDT R,GALOR A.Meibomian gland disease:the role of gland dysfunction in dry eye disease[J].Ophthalmology,2017,124(11s):S20-26.
[35] UZUNOSMANOGLU E,MOCAN M C,KOCABEYOGLU S,et al.Meibomian gland dysfunction in patients receiving long-term glaucoma medications[J].Cornea,2016,35(8):1112-1116.
[36] HAN X,YANG S,KAM W R,et al.The carbonic anhydrase inhibitor dorzolamide stimulates the differentiation of human meibomian gland epithelial cells[J].Curr Eye Res,2020,45(12):1604-1610.
[37] BELMONTE C,NICHOLS J J,COX S M,et al.TFOS DEWS II pain and sensation report[J].Ocul Surf,2017,15(3):404-437.
[38] GRANT C R,LIBERAL R,MIELI-VERGANI G,et al.Regulatory T-cells in autoimmune diseases:challenges,controversies and--yet--unanswered questions[J].Autoimmun Rev,2015,14(2):105-116.
[39] DE PAIVA C S,HWANG C S,PITCHER J D,3rd,et al.Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice[J].Rheumatology(Oxford),2010,49(2):246-258.
[40] STEPP M A,PAL-GHOSH S,TADVALKAR G,et al.Reduced corneal innervation in the CD25 null model of sjogren syndrome[J].Int J Mol Sci,2018,19(12):3821.
[41] BENJAMIN D,COLOMBI M,MORONI C,et al.Rapamycin passes the torch:a new generation of mTOR inhibitors[J].Nat Rev Drug Discov,2011,10(11):868-880.
[42] SHAH M,EDMAN M C,JANGA S R,et al.A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome[J].J Control Release,2013,171(3):269-279.
[43] CHO B J,HWANG J S,SHIN Y J,et al.Rapamycin rescues endoplasmic reticulum stress-induced dry eye syndrome in mice[J].Invest Ophthalmol Vis Sci,2019,60(4):1254-1264.
[44] SHAH M,EDMAN M C,JANGA S R,et al.Rapamycin eye drops suppress lacrimal gland inflammation in a murine model of sjogren's syndrome[J].Invest Ophthalmol Vis Sci,2017,58(1):372-385.
[45] TRUJILLO-VARGAS C M,KUTLEHRIA S,HERNANDEZ H,et al.Rapamycin eyedrops increased CD4(+)Foxp3(+) cells and prevented goblet cell loss in the aged ocular surface[J].Int J Mol Sci,2020,21(23):8890.
[46] MATSUO T,TSUCHIDA Y,MORIMOTO N.Trehalose eye drops in the treatment of dry eye syndrome[J].Ophthalmology,2002,109(11):2024-2029.
[47] PANIGRAHI T,SHIVAKUMAR S,SHETTY R,et al.Trehalose augments autophagy to mitigate stress induced inflammation in human corneal cells[J].Ocular Surface,2019,17(4):699-713.
[48] MORYA A K,SOLANKI K,PRAKASH S,et al.Randomized controlled trial of trehalose:An efficient autophagic bioprotectant in the management of dry eye disease[J].Taiwan J Ophthalmol,2021,11(2):161-167.
[49] ZHANG X,CHEN S,SONG L,et al.MTOR-independent,autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis[J].Autophagy,2014,10(4):588-602.
[50] LIU Z,CHEN D,CHEN X,et al.Trehalose induces autophagy against inflammation by activating TFEB signaling pathway in human corneal epithelial cells exposed to hyperosmotic stress[J].Invest Ophthalmol Vis Sci,2020,61(10):26.
[51] HERNANDEZ E,TAISNE C,LUSSIGNOL M,et al.Commercially available eye drops containing trehalose protect against dry conditions via autophagy induction[J].J Ocul Pharmacol Ther,2021,37(7):386-393.
[52] CHITIMUS D M,POPESCU M R,VOICULESCU S E,et al.Melatonin's impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease[J].Biomolecules,2020,10(9):1211.
[53] WU J,BAI Y,WANG Y,et al.Melatonin and regulation of autophagy:Mechanisms and therapeutic implications[J].Pharmacol Res,2021,163:105279.
[54] WANG B,ZUO X,PENG L,et al.Melatonin ameliorates oxidative stress-mediated injuries through induction of HO-1 and restores autophagic flux in dry eye[J].Exp Eye Res,2021,205:108401.
[55] XU J,CHEN P,ZHAO G,et al.Copolymer micelle-administered melatonin ameliorates hyperosmolarity-induced ocular surface damage through regulating PINK1-mediated mitophagy[J].Curr Eye Res,2022,47(5):688-703.
[56] DAI Y,ZHANG J,XIANG J,et al.Calcitriol inhibits ROS-NLRP3-IL-1β signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells[J].Redox Biol,2019,21:101093.
[57] LYU N,ZHANG J,DAI Y,et al.Calcitriol inhibits apoptosis via activation of autophagy in hyperosmotic stress stimulated corneal epithelial cells in vivo and in vitro[J].Exp Eye Res,2020,200:108210.
[58] CHU C,HUANG Y,RU Y,et al.α-MSH ameliorates corneal surface dysfunction in scopolamine-induced dry eye rats and human corneal epithelial cells via enhancing EGFR expression[J].Exp Eye Res,2021,210:108685.
[59] ZHANG X,YIN Y,YUE L,et al.Selective serotonin reuptake inhibitors aggravate depression-associated dry eye via activating the NF-κB pathway[J].Invest Ophthalmol Vis Sci,2019,60(1):407-419.
[60] ZHOU X,DAI Y,ZHAI Z,et al.WAY-100635 alleviates corneal lesions through 5-HT1A receptor-ROS-autophagy axis in dry eye[J].Front Med(Lausanne),2021,8:799949. |
