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中性粒细胞与肺纤维化关系的研究进展
作者:王煜州1  孙票票1  孙玉恒2  沙晓娟1  巢杰1  王静1 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学 公共卫生学院, 江苏 南京 210009
关键词:肺纤维化 中性粒细胞 趋化 脱颗粒 中性粒细胞胞外陷阱 综述 
分类号:R563.9
出版年·卷·期(页码):2023·42·第一期(149-153)
摘要:

肺纤维化是一种慢性间质性肺疾病,其发病机制尚未完全阐明,目前缺少有效治疗手段,晚期肺纤维化患者生活质量显著降低。中性粒细胞是先天免疫系统中的重要细胞,可以抵御外来微生物的入侵且参与炎症诱导的损伤。在肺纤维化进展过程中中性粒细胞水平发生明显改变,且这种变化与肺纤维化的发生发展可能密切相关。本文作者对中性粒细胞与肺纤维化关系的研究进展作一综述,以期为临床肺纤维化诊疗提供借鉴。

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