结直肠癌是世界范围内最常见的恶性肿瘤之一，近年来发病率成逐渐上升的趋势，治疗方法为外科手术切除为主，放化疗及靶向治疗为辅。随着微创外科技术的迅速发展，机器人手术系统应用于直肠癌手术治疗呈现出良好的安全性和可靠性等优势。研究显示，直肠癌手术围手术期中常用的麻醉剂右美托咪定可能影响免疫活性细胞的功能、应激激素的分泌以及炎症介质的基因表达，对术后肿瘤迁移具有一定影响，然而其在机器人直肠癌手术围手术期中对肿瘤迁移的影响鲜有报道。本文作者就机器人直肠癌手术围手术期中右美托咪定对肿瘤迁移可能产生的影响进行综述，以期为右美托咪定在机器人直肠癌手术的应用提供科学参考。

[1] SIEGEL R, MA J M, ZOU Z H, et al.Cancer statistics, 2014[J].CA Cancer J Clin, 2014, 64(1):9-29.
[2] PARK J J, CHAN K K, PARK S Y, et al.Value of diffusion-weighted imaging in predicting parametrial invasion in stage ⅠA2-ⅡA cervical cancer[J].Eur Radiol, 2014, 24(5):1081-1088.
[3] WILKINSON N.Management of rectal cancer[J].Surg Clin North Am, 2020, 100(3):615-628.
[4] SHIN J W, KIM J, KWAK J M, et al.First report:robotic pelvic exenteration for locally advanced rectal cancer[J].Colorectal Dis, 2014, 16(1):9-14.
[5] DONG W, CHEN M H, YANG Y H, et al.The effect of dexmedetomidine on expressions of inflammatory factors in patients with radical resection of gastric cancer[J].Eur Rev Med Pharmacol Sci, 2017, 21(15):3510-3515.
[6] CHIANG S P H, CABRERA R M, SEFALL J E.Tumor cell intravasation[J].Am J Physiol Cell Physiol, 2016, 311(1):C1-C14.
[7] SHI J G, YANG F J, JU X B, et al.Comparative study on dosimetry of VAMT and IMRT in assisted radiotherapy after radical resection of rectal cancer[J].Oncol Lett, 2017, 13(5):2971-2974.
[8] NASR D A, ABDELHAMID H M.The effificacy of caudal dexmedetomidine on stress response and postoperative pain in pediatric cardiac surgery[J].Ann Card Anaesth, 2013, 16(2):109-114.
[9] LI S Y, LI H, MA Y S.Comparison of intracenous lidocaine and dexmedetomidine infusion for prevention of postoperative catheter related bladder discomfort:a randomized controlled trial[J].BMC Anesthesiol, 2019, 19(1):37.
[10] URH A, JAMES N, HAN A, et al.Determination of HE4-mediated roles in tumor immune system modulation in epithelial ovarian cancer(EOC)[J].Gynecol Oncol, 2015, 137(3):174.