目的：探讨一次性子宫内膜取样器在子宫内膜门诊评估随访中的使用价值。方法：收集无锡市锡山人民医院妇科门诊2018年3月至2020年3月期间经诊刮确诊为子宫内膜增生而行孕激素治疗，需定期随访内膜的患者200例，按随机数字表分成实验组和对照组两组，实验组采用一次性内膜取样器获取内膜，对照组采用常规诊刮术获取内膜，观察比较病理医师对两组标本的取材满意度、两组术中疼痛评分、手术出血量、手术并发症以及患者定期随访的依从性。结果：两组病理标本取材满意度均为100%。实验组与对照组相比，手术时间明显缩短[（55.89±15.98） s vs（457.5±150.4） s]、术中出血减少[（2.24±1.19） ml vs（12.50±6.82） ml]、术中不适发生率低（5.5%vs 67.2%）、术中疼痛评分低、术后随访依从性好，差异均有统计学意义。结论：子宫内膜取样器操作简单、疼痛轻、取材满意度好，在门诊随访内膜时可提高患者依从性，或可取代常规诊刮术。

[1] 张建青.复发性子宫内膜增生症处理原则[J].中国实用妇科与产科杂志, 2016, 32(11):1075-1078.
[2] VAN DER MEER A C, HANANA L S.Development of endometrioid adenocarcinoma despite Levonorgestrel-releasing intrauterine system:a case report with discussion and review of the RCOG/BSGE Guideline on the Management of Endometrial Hyperplasia[J].Clin Obe, 2017, 7(1):54-57.
[3] AUCLAIR M H, YONG P J, SALVADOR S, et al.Guideline No. 392-Classification and Management of Endometrial Hyperplasia[J].J Obstet Gynaecol Can, 2019, 41(12):1789-1800.
[4] 孟宪华, 王晓红, 张延涛, 等.与乳腺癌内分泌治疗相关子宫内膜病变的管理[J].中国实用妇科与产科杂志, 2020, 36(4):374-376.
[5] 刁雯静, 郭奇桑, 宋昱, 等.子宫内膜取样器与传统诊刮术对于子宫内膜评估及诊断价值的比较[J].复旦学报(医学版), 2014, 41(6):803-807.
[6] 谢幸, 孔北华, 段涛.妇产科学[M].9版.北京:人民卫生出版社, 2018:411.
[7] GARRA G, SINGER A J, DOMING A, et al.The Wong-Baker pain FACES scale measures pain, not fear[J].Pediatr Emerg Care, 2013, 29(1):17-20.
[8] HIRAI Y, SAKAMOTO K, FUJIWARA H, et al.Liquid-based endometrial cytology using SurePath is not inferior to suction endometrial tissue biopsy for detecting endometrial malignancies:midterm report of a multicentre study advocated by Japan Association of Obstetricians and Gynecologists[J].Cytopathology, 2019, 30(2):223-228.
[9] JIANG D, YALING L, SHULAN L, et al.Endometrial sampling devices for early diagnosis of endometrial lesions[J].J Cancer Res Clin Oncol, 2016, 142(12):2515-2522.
[10] SANAM M, MAJID M.Comparison the diagnostic value of dilatation and curettage versus endometrial biopsy by pipelle-a clinical trial[J].Asian Pac J Cancer Prev, 2015, 16(12):4971-4975.
[11] BEHNAMFAR F, ARSHAD E.Diagnostic values of pipelle and standard curettage compared to hysterectomy pathology in postmenopausal bleeding:a comparative study[J].Adv Biomed Res, 2020, 9:58.
[12] AGOSTINI A, SHOJAI R, CRAVELLO L, et al.Endometrial biopsy during outpatient hysteroscopy:evaluation and comparison of two devices[J].Eur J Obstet Gynecol Reprod Biol, 2001, 97(2):220-222.
[13] 苏椿淋, 李昕, 林金芳.子宫内膜不典型增生及早期子宫内膜样癌药物治疗的进展及前景[J].中华妇产科杂志, 2015(9):715-717.