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肺移植期间肺缺血再灌注损伤及药物治疗的研究进展
作者:王净1  胡春兰1  于慧智1  李小杉2  胡春晓3 
单位:1. 南京医科大学附属无锡人民医院 麻醉科, 江苏 无锡 214023;
2. 南京医科大学附属无锡人民医院 肺移植中心, 江苏 无锡 214023;
3. 南京医科大学附属无锡人民医院 移植麻醉科, 江苏 无锡 214023
关键词:肺缺血再灌注损伤 肺移植 原发性移植物功能障碍 综述 
分类号:R655
出版年·卷·期(页码):2022·41·第四期(578-582)
摘要:

肺缺血再灌注损伤(LIRI)是发生在肺移植术后的一种急性肺损伤(ALI),是术后发生原发性移植物功能障碍(PGD)的主要危险因素。近年研究发现乌司他丁、伊马替尼、前列地尔等多种临床药物有减轻LIRI的作用。作者综述已有药物对LIRI的保护作用及其机制,为LIRI预防和治疗的进一步研究提供思路。

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