Objective: To assess perioperative autonomic nervous function by monitoring heart rate variability(HRV)in patients with colorectal cancer to explored its relationship with nutrition and rehabilitation. Methods: 28 patients with colorectal cancer were divided into no nutritional risk group(A group) and high nutritional risk group(B group) based on comprehensive nutritional risk assessment. The changes of body composition, HRV and serum nutritional indicators were monitored, and the differences and correlation of indexes between and within groups of nutritional indexes and HRV indexes were explored. Results: Compared with preoperative HRV, PNN50 increased significantly on operative day in group A(P<0.05), LF and HF also increased significantly(P<0.05), and LF/HF decreased significantly(P<0.05). In group B, the comparison of operative day and preoperative day showed the same trend. There was a statistical difference in PNN50 and HF between group A and group B(P<0.05). In group A, there were no significant differences in PNN50, LF, HF and LF/HF between preoperative and postoperative HRV(P>0.05). In group B, PNN50, LF and HF of group B were significantly higher than those before operation(P<0.05). Postoperative PNN50 and HF of group B were significantly higher those in group A(P<0.05). Correlation analysis of HRV and nutritional indexes showed that PNN50 was significantly correlated with body weight, fat group, albumin and transferrin(all r≠0, P<0.05), HF was significantly correlated with body weight, BMI, fat group and transferrin(all r≠0, P<0.05), and LF/HF was significantly correlated with body weight, total body moisture, muscle group and total protein(all r≠0, P<0.05). Conclusion: Autonomic nervous function, especially vagus nerve function, is correlated with perioperative nutritional status and rehabilitation. HRV monitoring provides a new idea for nutritional evaluation and nutritional support of tumor patients. |
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