FoxP3<sup>+</sup>调节性T细胞与胆道癌患者预后相关性的Meta分析-东南大学学报医学版

FoxP3⁺调节性T细胞与胆道癌患者预后相关性的Meta分析

单位：1. 南京医科大学逸夫医院肿瘤科, 江苏南京 211166;
2. 南京医科大学第一附属医院肿瘤科, 江苏南京 210029;
3. 南京市中医院肿瘤科, 江苏南京 210000;
4. 南京医科大学第一附属医院胸外科, 江苏南京 210029

关键词：胆道癌 FoxP3⁺ 调节性T细胞预后 Meta分析

分类号：R735.8

出版年·卷·期（页码）：2022·41·第三期（317-325）

摘要：

目的：通过Meta分析探究肿瘤浸润性FoxP3⁺调节性T细胞（regulatory T cells，Tregs）在评估胆道癌预后方面的价值。方法：检索PubMed、Web of Science、Embase、中国知网、中国生物医学文献数据库、维普和万方数据库，收集所有关于肿瘤浸润性FoxP3⁺ Tregs与胆道肿瘤患者预后关系的文献，检索时间从建库至2021年1月10日。经过文献筛选后，由2名研究者独立提取数据。应用STATA 12.0软件进行Meta分析，用HR及其对应的95%CI评估FoxP3⁺ Tregs与胆道癌患者总生存期（overall survival，OS）的相关性。结果：最终纳入10篇文献。Meta分析结果表明，高FoxP3⁺ Tregs浸润的胆道癌患者具有更差的OS（HR=1.47，95%CI 1.10~1.96）。对胆囊癌和胆管癌进行的分层分析显示，FoxP3⁺ Tregs的高浸润与前者的OS显著相关（HR=1.63，95%CI 1.25~2.13），而与后者的OS无关（HR=1.21，95%CI 0.78~1.88）。结论：肿瘤浸润性FoxP3⁺ Tregs可作为胆道肿瘤预后的生物标志物，而它在胆管癌中确切的预后价值还需更多研究加以验证。

Objective: To explore the value of tumor-infiltrating FoxP3⁺ regulatory T cells(Tregs) in evaluating the prognosis of biliary tract cancer(BTC) by Meta-analysis. Methods: We searched PubMed, Web of Science, Embase, Chinese NCKI, China Biology Medicine, VIP and Wanfang Database for relevant literature until January 10, 2021. After screening all eligible publications, two investigators extracted data independently. A Meta-analysis was conducted to calculate pooled HR and 95%CI for overall survival(OS). All statistical analyses were presented by STATA version 12.0. Results: Ten studies were finally enrolled. The pooled analysis revealed that FoxP3⁺ Treg was a poor prognostic marker for OS in patients with BTC(HR=1.47, 95%CI 1.10-1.96). Interestingly, stratified analysis of gallbladder cancer and cholangiocarcinoma showed that high infiltration of FoxP3⁺ Tregs was significantly associated with the OS of gallbladder cancer(HR=1.63, 95%CI 1.25-2.13), but not with the OS of cholangiocarcinoma(HR=1.21, 95%CI 0.78-1.88). Conclusion: Our Meta-analysis demonstrated that tumor-infiltrating FoxP3⁺ Tregs can be a prognostic biomarker in BTC. More studies are needed to define the exact prognostic value of FoxP3⁺ Tregs in cholangiocarcinoma.

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