Objective: To observe the efficiency of level of microRNA-25-3p(miR-25-3p) in tissues combined with spectral CT quantitative parameters in predicting the prognosis of patients with non-small cell lung cancer(NSCLC) after pulmonary lobectomy.Methods: 116 patients with NSCLC admitted to our hospital from January 2017 to January 2019 were retrospectively selected as the research subjects, the baseline data were recorded, the level of miR-25-3p in tissues was detected before treatment, chest spectral CT was performed. All patients underwent pulmonary lobectomy, the patients were followed up for 19-24 months to evaluate their prognosis, recurrence was taken as the end point. According to the recurrence, the patients were divided into a poor prognosis group and a good prognosis group, baseline data, level of miR-25-3p in tissues and quantitative parameters of spectral CT were compared between the two groups, the predictive efficiency of level of miR-25-3p in tissues combined with spectral CT quantitative parameters on the prognosis of NSCLC patients after pulmonary lobectomy was analyzed.Results: The patients were followed up for 19-24 months, recurrence was taken as the end point, the average follow-up time was(20.68±3.59) months, the recurrence rate of 116 cases of patients with NSCLC was 17. 24%; the recurrence curve was drawn by KM method, in 20 patients with recurrent NSCLC, the recurrence time was 18 months(95% confidence interval:15.809-20.191 months); the baseline data, miR-25-3p and spectral CT quantitative parameters were preliminarily compared between poor prognosis group and good prognosis group, through proportional hazard regression mode analysis, the results showed that lymph node metastasis, TNM stage, relative expression of miR-25-3p, plain scan Eff-Z, NIC in venous phase and arterial phase were the influencing factors of prognosis in patients with NSCLC after pulmonary lobectomy(P<0.05); the receiver operating characteristics curve was drawn, the results showed that the area under the curve of level of miR-25-3p in tissues combined with spectral CT quantitative parameters in predicting the prognosis of patients was greater than 0.85, which had certain predictive value.Conclusion: Level of miR-25-3p in tissues combined with spectral CT quantitative parameters has certain predictive efficiency in predicting the prognosis of NSCLC patients after pulmonary lobectomy. |
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