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锌指蛋白家族的转录调控模式及其对肿瘤细胞发展进程的影响
作者:张文武1 2  肖斌1  宋筱羽1  孙朝晖3  李林海1 
单位:1. 广州医科大学附属第六医院, 清远市人民医院 检验医学部, 广东 清远 511500;
2. 广州中医药大学, 广东 广州 510010;
3. 中国人民解放军南部战区总医院 检验科, 广东 广州 510010
关键词:锌指蛋白 转录调控 肿瘤发展进程 综述 
分类号:Q513
出版年·卷·期(页码):2021·40·第六期(860-864)
摘要:

锌指蛋白(ZFPs)是人类基因组中最大的转录因子家族, 具有广泛的分子生物学功能, 参与DNA的识别修复、RNA包装、信号传导、转录调控等重要进程。多种ZFPs已被证实在不同类型肿瘤细胞中高表达, 其表达水平与肿瘤的发生发展密切相关。ZFPs具有多种转录调控模式, 不同的转录调控模式对于下游基因表达的启动和激活具有重要意义。本文作者就ZFPs在肿瘤细胞中的转录调控机制及其对肿瘤细胞发展进程的影响进行简要综述。

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