宁波某企业体检人群甲状腺结节检出率及其影响因素分析-东南大学学报医学版

宁波某企业体检人群甲状腺结节检出率及其影响因素分析

单位：1. 宁波市镇海区炼化医院内科, 浙江宁波 315207;
2. 常州市新北区奔牛人民医院内科, 江苏常州 213131;
3. 中山大学附属第三医院特诊医疗中心, 广东广州 510630

分类号：R581

出版年·卷·期（页码）：2021·40·第六期（820-825）

摘要：

目的: 了解宁波某企业体检人群中甲状腺结节检出率, 并分析相关影响因素。方法: 收集宁波某大型国有企业5 416名体检人员的体检资料。将人群分为甲状腺结节组与非甲状腺结节组, 组间比较根据数据类型分别用两独立样本t检验、χ²检验进行分析, 并用多因素Logistic回归分析受检人群中甲状腺结节检出率的影响因素。结果: 甲状腺结节总检出率为35.8%, 其中女性为48.4%, 男性为32.6%;不同年龄段女性检出率均高于男性, 且甲状腺结节检出率随年龄增长而显著升高(P < 0.05)。多因素Logistic回归分析显示, 性别、年龄和腰围是甲状腺结节的可能影响因素(P < 0.05)。结论: 宁波某企业体检人群中女性甲状腺结节检出率明显高于男性, 性别、年龄和腰围与甲状腺结节有显著相关性。

Objective: To investigate the detection rate of thyroid nodules in physical examination population of an enterprise in Ningbo and analyze the related influence factors.Methods: The physical examination data of 5 416 physical examinees in a large state-owned enterprise in Ningbo were collected.The data were compared between the individuals with and without thyroid nodules using two independent samples t test and Chi-square test. Multivariate Logistic regression was used to analyze the relationship between different factors and thyroid nodules.Results: The total detection rate of thyroid nodules was 35.8%, and the detection rate of woman was 48.4%, while that of men was 32.6%; the detection rate of thyroid nodules increased significantly with age, and the detection rates of women in different age groups were higher than those of men (P < 0.05). Multivariate Logistic regression analysis showed that the gender, age and waist circumference were possible influence factors for thyroid nodules (P < 0.05).Conclusion: The detection rate of thyroid nodules is much higher in female than in male individuals in an enterprise in Ningbo, and there is a significant correlation between gender, age, waist circumference and thyroid nodules.

参考文献：

[1] 郭奕瑞, 刘颖, 张莉. 健康体检人群甲状腺结节患病率及相关因素分析[J]. 现代预防医学, 2016, 43(22): 4063-4065.
[2] 于钏钏, 王强. 2008—2014年我国健康成人甲状腺结节流行特征及影响因素初步分析[J]. 环境与健康杂志, 2016, 33(5): 440-443.
[3] 朱砚, 李敬华, 王素莉, 等. 甲状腺结节病因及危险因素的研究进展[J]. 现代中西医结合杂志, 2016, 25(15): 1701-1703.
[4] ALAN P, HOSSEIN G. Epidemiology of thyroid nodules[J]. Best Pract Res Cl En, 2018, 22 (6): 901-905.
[5] 中国成人血脂异常防治指南修订联合委员会. 中国成人血脂异常防治指南(2016年修订版)[J]. 中华心血管病杂志, 2016, 44(10): 833-853.
[6] 中华人民共和国卫生和计划生育委员会. WS/T 428-2013成人体重判定[S]. 北京: 中国标准出版社, 2013.
[7] 中国肥胖问题工作组. 中国成人超重和肥胖症预防与控制指南(节录)[J]. 营养学报, 2004, 26(1): 1-4.
[8] 廖二元. 内分泌代谢病学[M]. 3版. 北京: 人民卫生出版社, 2014.
[9] 中华医学超声杂志(电子版)编辑委员会浅表器官学组. 甲状腺结节超声诊断规范[J]. 中华医学超声杂志(电子版), 2017, 14(4): 241-244.
[10] JAMES W. Thyroid nodules[J]. JAMA Otolaryngol, 2020, 146(6): 596.
[11] 温静. 健康体检中超声检查对甲状腺结节的诊断与分析[J]. 武警后勤学院学报(医学版), 2013, 22(5): 434-435.
[12] DEBORAH F, DIMITRI S, DENIS N, et al. Molecular imaging of galectin-1 expression as a biomarker of papillary thyroid cancer by using peptide-functionalized imaging probes[J]. Biology, 2020, 9(3): 53-77.
[13] HAUGEN B R, ALEXANDER E K, BIBLE K C, et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer[J]. Thyroid, 2016, 26(1): 1-133.
[14] 战英杰, 王景. 1600名健康体检人群甲状腺结节筛查结果及患病危险因素Logistic回归分析[J]. 中国中西医结合耳鼻咽喉科杂志, 2017, 25(4): 309-312.
[15] 王倩, 陈英艳. 健康体检人群甲状腺结节患病情况及相关危险因素分析[J]. 中国医学前沿杂志(电子版), 2017, 9(10): 183-187.
[16] 李晓慧, 徐岐山, 王卫芳. 太原地区健康体检人群甲状腺结节患病率及危险因素分析[J]. 中国地方病防治杂志, 2018, 33(2): 121-124.
[17] 于晓会, 单忠艳. 甲状腺结节的病因与流行病学趋势[J]. 中国普外基础与临床杂志, 2011, 18(8): 800-802.
[18] 徐厚兰, 危静, 兰满, 等. 11268名健康体检人群甲状腺结节发生的流行状况调查分析[J]. 疾病监测, 2014, 29(12): 987-991.
[19] 胡玉藏, 吴俊, 倪文璐, 等. 开封市社区居民甲状腺结节患病情况调查及影响因素分析[J]. 河南医学研究, 2019, 28(2): 210-212.
[20] 龚家权, 陈鹏, 刘悦, 等. 东莞市塘厦镇劳务工人群中甲状腺结节患病情况调查及其对策[J]. 心血管外科杂志(电子版), 2019, 8(1): 98-99.
[21] MOON J H, HYUN M K, LEE J Y, et al. Prevalence of thyroid nodules and their associated clinical parameters: a large-scale, multicenter-based health checkup study[J]. Korean J Intern Med, 2018, 33(4): 753-762.
[22] KUNG A W, CHAU M T, LAO T T, et al. The effect of pregnancy on thyroid nodule formation[J]. J Clin Endocrinol Metab, 2002, 87(3): 1010-1014.
[23] VIVACQUA A, BONOFIGLIO D, ALBANITO L, et al. 17beta-estradiol, genistein, and 4-hydrexytamoxifen induce the proliferation of thyroid cancer cells through the G protein-cou plod receptor GPR30[J]. Mol Pharmacol, 2006, 70(4): 1414-1423.
[24] 林旋, 郎江明, 魏爱生, 等. 健康体检人群甲状腺结节发病危险因素的病例对照研究[J]. 广东医学, 2018, 39(4): 604-607.
[25] GUO H, SUN M, HE W, et al. The prevalence of thyroid nodules and its relationship with metabolic parameters in a Chinese community-based population aged over 40 years[J]. Endocrine, 2014, 45(2): 230-235.
[26] 周琦, 李诗骜, 姜珏, 等. 超声造影鉴别甲状腺钙化结节性质及其与年龄、性别的相关性分析[J]. 中华超声影像学杂志, 2016, 25(4): 313-316.
[27] LIU J F, WANG C G, TANG X L, et al. Correlation analysis of metabolic syndrome and its components with thyroid nodules[J]. Diabetes Metab Syndr Obes, 2019, 12: 1617-1623.
[28] SU Y, ZHANG Y L, ZHAO M, et al. Association between thyroid nodules and volume and metabolic syndrome in an iodine-adequate area: a large community-based population study[J]. Metab Syndr Relat Disord, 2019, 17(4): 217-222.
[29] SONG B, ZUO Z, TAN J, et al. Association of thyroid nodules with adiposity: a community-based cross-sectional study in China[J]. BMC EndocrDisord, 2018, 18(1): 3-11.
[30] 金志萍, 张珊, 于雪梅, 等. 社区2型糖尿病患者甲状腺结节危险因素研究分析[J]. 上海交通大学学报(医学版), 2018, 38(9): 1066-1071.
[31] TRAYHURN P, WOOD I S. Adipokines: inflammation and the pleiotropic role of white adipose tissue[J]. Br J Nutr, 2004, 92(3): 347-355.
[32] 韩青. 代谢综合征患者胰岛素抵抗程度与甲状腺结节的相关性研究[J]. 中国实验诊断学, 2016, 20(6): 915-918.
[33] 张春玉, 曾洪利, 刘颖, 等. 甲状腺结节与代谢综合征及其组分的相关性分析[J]. 中华内分泌代谢杂志, 2012, 28(2): 132-135.

服务与反馈：

【文章下载】【发表评论】【查看评论】【加入收藏】

提示：您还未登录，请登录！点此登录