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子痫前期患者胎盘血管生成情况的评估
作者：朱莉娜1 2 3  李萱1 2 3  于震1 2 3  杨媛媛1 2 3 
单位：1. 安徽医科大学第一附属医院 妇产科, 安徽 合肥 230000;
2. 国家卫生健康委配子及生殖道异常研究重点实验室, 安徽 合肥 230000;
3. 生殖健康与遗传安徽省重点实验室, 安徽 合肥 230000
关键词：子痫前期 胎盘 血管生成 
分类号：R714.244
出版年·卷·期（页码）：2021·40·第六期（785-789）
摘要：

目的: 探讨子痫前期患者胎盘血管生成情况。方法: 选取2020年5月至12月在安徽医科大学第一附属医院妇产科分娩的40例子痫前期患者作为病例组, 选取同时期分娩的40例血压正常、无其他妊娠并发症的产妇作为对照组。比较两组人群年龄、孕期增重、血压和妊娠结局的差异。以CD34为内皮标志物, 采用免疫组化法对胎盘血管生成情况进行分析, 并根据每视野下CD34+血管数对个体血管生成情况进行等级划分, 比较两组的差异。结果: 两组年龄、体重指数(BMI)和孕期增重差异无统计学意义(P > 0.05), 病例组患者血压(收缩压和舒张压)明显高于对照组(P < 0.01)。与对照组相比, 病例组患者分娩孕周明显缩短, 胎盘重也明显降低, 胎儿出生体重、身长、头围也明显降低或缩短, 即刻及1、5 min Apgar评分明显降低(均P < 0.05)。免疫组化结果显示, 病例组患者胎盘血管生成减少, 其胎盘血管生成能力主要是低等级。按照免疫组化胎盘血管生成等级将研究对象分为高水平组、中水平组和低水平组。与高水平组和中水平组相比, 低水平组孕期血压(收缩压和舒张压)升高, 孕周缩短, 胎儿出生体重、身长、头围和胎盘重降低或缩短, 即刻及1、5 min Apgar评分降低(P < 0.05)。结论: 子痫前期患者胎盘血管生成减少, 探明其原因对于子痫前期的预防具有重要意义。

Objective: To investigate the condition of placental angiogenesis in preeclampsia patients.Methods: 40 cases of preeclampsia patients who delivered in the Department of Gynecology and Obstetrics of the First Affiliated Hospital of Anhui Medical University from May 2020 to December 2020 were selected as the case group, and 40 cases of parturients with normal blood pressure and no other pregnancy complications during the same period were selected as the control group. The differences in age, pregnancy weight gain, blood pressure and pregnancy outcome between the two groups were compared. Using CD34 as endothelial marker, the placental angiogenesis was compared by immunohistochemistry, and the individual angiogenesis was classified according to the number of CD34+ vessels per field of view, and the differences between the two groups were compared.Results: There was no difference in age, BMI, weight gain during pregnancy between the two groups (P < 0.05). Blood pressure (systolic and diastolic) of the case group was significantly higher than that of the control group (P < 0.01).Compared with the control group, the gestational week of the patients in the case group was significantly shorter, the placental weight was significantly decreased, the fetal birth weight, body length and head circumference were significantly decreased, and the immediate score, 1 min and 5 min Apgar score were significantly lower (P < 0.05). Immunohistochemistry results showed that placental angiogenesis was reduced in the case group, and grade analysis showed that placental angiogenesis was mainly of low grade. According to the grade of immunohistochemical placental angiogenesis, the patients were divided into high level group, medium level group and low level group. Compared with the high and medium level groups, the patients in the low level group had increased blood pressure (systolic and diastolic) during pregnancy, decreased gestational age, fetal birth weight, body length, head circumference, and placental weight, immediate score and 1 min, 5 min Apgar score(P < 0.05).Conclusion: Placental angiogenesis is decreased in patients with preeclampsia, and it is of great significance for the prevention of preeclampsia to find out the reason.
参考文献：

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