CSC患者黄斑色素光密度与视网膜中央厚度及脉络膜厚度的关系-东南大学学报医学版

CSC患者黄斑色素光密度与视网膜中央厚度及脉络膜厚度的关系

单位：1. 济宁医学院附属医院曹县分院眼科, 山东菏泽 274000;
2. 湖北省孝感市中心医院眼科, 湖北孝感 432000

分类号：R774.1

出版年·卷·期（页码）：2021·40·第五期（627-632）

摘要：

目的：探讨中心性浆液性脉络膜视网膜病变（CSC）患者黄斑色素光密度（MPOD）与视网膜中央厚度（CRT）及脉络膜厚度（CT）的关系。方法：纳入2个医院2018年5月-2021年1月收治的82例CSC患者（单侧患眼）作为CSC组，同时选取同期于该院体检的60例健康志愿者作为对照组。经单波长蓝光反射眼底成像客观测量法检测MPOD，利用光学相干断层扫描（OCT）检测CRT和CT值，其中CT值包括黄斑中心凹下脉络膜厚度（SFCT）、颞侧脉络膜厚度（TCT）、鼻侧脉络膜厚度（NCT）、下方脉络膜厚度（ICT）以及上方脉络膜厚度（SCT）。分别根据CSC患者的急性、慢性发病再分成急性组和慢性组，有无弥漫性视网膜色素上皮（RPE）萎缩而分成RPE萎缩组和无RPE萎缩组，比较相应组间上述各指标。经Pearson线性相关分析CSC患者MPOD与CRT、CT值的相关性。结果：CSC组患侧眼的平均光密度（OD）、最大OD低于CSC组对侧眼和对照组，而CRT、SFCT、TCT、NCT高于CSC组对侧眼和对照组（P<0.05）。慢性组的平均OD、最大OD低于急性组，且RPE萎缩组的CRT、SFCT低于无RPE萎缩组（P<0.05）。Pearson线性相关分析显示，CSC患者患侧眼的平均OD、最大OD与CRT、SFCT、TCT、NCT、ICT、SCT均无相关性（P>0.05）。结论：CSC患者MPOD明显下降，且CRT以及黄斑中心凹下、鼻侧、颞侧的CT值增高，但MPOD与CRT、CT未见相关性。

Objective: To investigate the relationship between macular pigment optical density (MPOD) and central retinal thickness (CRT) and choroidal thickness (CT) in patients with central serous chorioretinopathy (CSC). Methods: A total of 82 CSC patients admitted to our hospitals from May 2018 to January 2021 (a total of 82 unilateral eyes) were included as CSC group, and 60 healthy volunteers who received physical examination in the hospital during the same period were selected as control group. The objective measurement of single-wavelength blue light reflection fundus imaging was used to detect MPOD, and optical coherence tomography (OCT) was used to detect CRT and CT values. CT values included subfoveal choroidal thickness (SFCT), temporal choroidal thickness (TCT), and nasal side choroidal thickness (NCT), inferior choroidal thickness (ICT), and superior choroidal thickness (SCT). According to the acute and chronic onset of CSC patients, they were divided into acute group and chronic group. According to the presence or absence of diffuse retinal pigment epithelium (RPE) atrophy, they were divided into RPE atrophy group and no RPE atrophy group. The indicators of the two groups were compared and the correlation of MPOD and CRT, CT in CSC patients were analyzed using Pearson linear correlation. Results: Mean OD and max OD of the affected eye in the CSC group were lower than those of contralateral eyes in the CSC group and the control group, while CRT, SFCT, TCT, and NCT were higher than those of contralateral eyes in the CSC group and the control group (P<0.05). Mean OD and max OD of the chronic group were lower than those of the acute group, and the CRT and SFCT of the RPE atrophy group were lower than those of the no RPE atrophy group (P<0.05). Pearson linear correlation analysis showed that mean OD and max OD of the affected eye of CSC patients were not correlated with CRT, SFCT, TCT, NCT, ICT, SCT (P>0.05). Conclusion: MPOD decrease significantly in CSC patients, and the CT values of CRT and macular fovea, nasal and temporal sides increases, however there is no correlation between MPOD and CRT and CT.

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