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Ⅰ型子宫内膜癌患者血清PON-1活性与代谢综合征指标的相关性分析
作者:谷冀晖  豆秋彦 
单位:徐州医科大学附属连云港医院, 江苏 连云港 222000
关键词:对氧磷酶-1 子宫内膜癌 代谢综合征 
分类号:R737.33
出版年·卷·期(页码):2021·40·第五期(593-598)
摘要:

目的:探讨Ⅰ型子宫内膜癌患者血清对氧磷酶-1(paraoxonase-1,PON-1)活性与反映代谢综合征的指标(HDL-C、LDL-C、TG)之间的相关性。方法:选取自2019年1月至2020年9月于徐州医科大学附属连云港医院就诊的45例Ⅰ型子宫内膜癌患者(研究组)和50例正常子宫内膜患者(对照组)为研究对象,比较两组患者血清PON-1活性以及HDL-C、LDL-C、TG水平差异,并分析子宫内膜癌组患者不同临床病理分级分期血清PON-1活性的差异及PON-1活性与HDL-C、LDL-C、TG水平的关系。结果:研究组患者血清PON-1活性明显低于对照组(P<0.05),PON-1活性在子宫内膜癌患者的FIGO分期、分化程度、肌层浸润及淋巴转移间差异均有统计学意义(均P<0.05);研究组患者血清LDL-C、TG水平明显高于对照组(均P<0.05),HDL-C水平明显低于对照组(P<0.05);Ⅰ型子宫内膜癌患者血清PON-1活性与LDL-C、TG水平呈负相关(均r<0,P<0.05),与HDL-C水平呈正相关(r=0.123 3,P<0.05)。结论:PON-1活性可作为评估Ⅰ型子宫内膜癌病情严重程度的指标之一;Ⅰ型子宫内膜癌患者血清中也存在反映代谢综合征的相关指标的变化;PON-1可能是Ⅰ型子宫内膜癌与代谢综合征相互关联的重要因素之一。

Objective: To explore the correlation between serum paraoxonase-1(PON-1) activity and metabolic syndrome indicators in patients with type I endometrial cancer. Methods: We included 45 patients with type I endometrial cancer and 50 patients with normal endometrial who were treated at Lianyungang Hospital Affiliated to Xuzhou Medical University from January 2019 to September 2020 in the study. Serum PON-1 activity, HDL-C, LDL-C and TG levels were compared between the two groups. We analyzed the difference of serum PON-1 activity in patients with endometrial carcinoma in different clinical pathological grades and stages and relationship between PON-1 activity and HDL-C, LDL-C, TG levels. Results: Compared with patients in the normal endometrial group, the expression of serum PON-1 activity in the type I endometrial cancer group was significantly lower(P<0.05), and the degree of reduction was related to the FIGO stage, degree of differentiation, muscle invasion and lymphatic metastasis of patients with endometrial cancer with a statistically significant difference(P<0.05). Compared with the patients in the normal endometrial group, serum LDL-C and TG levels in the endometrial cancer group were significantly increased(all P<0.05), and the HDL-C level was significantly decreased(P<0.05). Serum PON-1 activity in patients with endometrial cancer was negatively correlated with LDL-C and TG levels(all r<0,P<0.05), and positively correlated with HDL-C levels(r=0.123 3,P<0.05). Conclusion: PON-1 activity can be used as one of the indicators to assess the severity of type I endometrial cancer. Changes of serum indicators of metabolic syndrome also exist in the patients with type I endometrial cancer. PON-1 may be one of the important factors in the correlation between type I endometrial cancer and metabolic syndrome.

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