目的：探究动态对比增强磁共振成像（DCE-MRI）评估肠缺血再灌注（IIR）导致肝损伤的价值。方法：将42只雄性大鼠随机分为6组，每组7只。假手术组只分离肠系膜血管不夹闭。缺血再灌注组分离肠系膜上动脉并用无创血管钳夹闭1 h，然后分别再灌注1、2、3、4 h。单纯缺血组分离肠系膜上动脉后选用7 mm手术缝合线扎紧肠系膜上动脉1 h。所有大鼠均行上腹部常规扫描和DCE-MRI扫描，扫描结束后测量相关血清学指标天冬氨酸转氨酶和丙氨酸氨基转移酶，同时对肝脏进行病理损伤评分。结果：不同缺血再灌注时间的容积转运常数（K^trans）和血管外细胞外间隙容积（V_e）差异具有统计学意义（P<0.05）。在所有组和缺血再灌注组中，K^trans和V_e均与病理评分呈显著正相关（均P<0.001）。K^trans和V_e的AUC分别为0.917和0.894。结论：DCE-MRI技术中的定量参数对微循环和血管通透性的改变较敏感，能够动态反应IIR诱导的早期肝损伤。

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