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PINK1/Parkin信号通路调控线粒体自噬在敌草快中毒神经元损伤中作用的研究进展
作者:吴瑾1  陆元兰1  张炉英1  胡杰2  岑祥莹1  喻安永1  谢智慧3 
单位:1. 遵义医科大学附属医院 急诊科, 贵州 遵义 563003;
2. 遵义医科大学附属医院 重症医学科, 贵州 遵义 563003;
3. 遵义医科大学附属医院 高压氧科, 贵州 遵义 563003
关键词:PINK1/Parkin 线粒体自噬 敌草快 神经元损伤 综述 
分类号:R595.4;R393
出版年·卷·期(页码):2021·40·第二期(238-242)
摘要:

随着敌草快(DQ)的应用增多,临床上的中毒病例也逐渐增多,但对于DQ神经损伤的机制仍不明确,且无有效的治疗措施,因此其神经损伤问题成为了人们关注的热点。机体发生急性DQ中毒时产生的氧化应激作用使体内线粒体电子传递链破坏后产生过多有害活性氧,诱导线粒体损伤,最终导致神经细胞死亡;神经保护蛋白PTEN诱导的假定激酶1(PINK1)及Parkin组成自噬通路,介导受损线粒体的自噬清除以维持神经元正常功能。作者就PINK1/Parkin信号通路调控线粒体自噬与DQ中毒神经元损伤之间的关系作一综述,进一步阐述DQ中毒神经元损伤的机制,展望DQ中毒神经元损伤治疗新方向。

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