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FABP1在胃癌中的研究进展
作者:范海华  刘燕文 
单位:东南大学 医学院, 江苏 南京 210009
关键词:肝型脂肪酸结合蛋白 胃癌 肝转移 腹膜转移 脂质代谢 综述 
分类号:R735.2
出版年·卷·期(页码):2021·40·第二期(234-237)
摘要:

胃癌位居国内消化道恶性肿瘤死亡率首位,60%晚期胃癌患者主要因转移至肝脏和腹膜死亡,目前需要早期诊断以降低死亡率,而临床常用的诊断标志物癌胚抗原(CEA)敏感度、特异性不高,且存在假阴性。因此,我们需要寻找其他标志物以提高胃癌诊断准确性。胃癌是一类代谢异常的疾病,其发生和转移与脂质异常代谢密切相关。研究人员已经在多种恶性肿瘤中发现血清肝型脂肪酸结合蛋白(FABP1)水平升高,预示体内脂质异常代谢。FABP1可能是胃癌诊断和转移潜在的靶点。作者对FABP1在胃癌发生及相关转移中的表达和作用机制作一综述。

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