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补充维生素D治疗对自身免疫性甲状腺炎患者甲状腺自身抗体水平影响的Meta分析
作者:刘思琪1  王苏1  吴亚平1  赵一璟1  左志华1  刘超2  王昆1 
单位:1. 南京医科大学附属江宁医院 内分泌科, 江苏 南京 211100;
2. 江苏省中西医结合医院 内分泌科, 江苏 南京 210028
关键词:维生素D 自身免疫性甲状腺炎 甲状腺过氧化物酶抗体 甲状腺球蛋白抗体 Meta分析 
分类号:R581.4
出版年·卷·期(页码):2021·40·第二期(207-213)
摘要:

目的:通过Meta分析评估维生素D对自身免疫性甲状腺炎(AIT)患者自身抗体水平的影响。方法:使用计算机检索PubMed、Embase、Cochrane图书馆、中国知网、万方和维普数据库中所有评估接受维生素D治疗的AIT患者甲状腺过氧化物酶抗体(TPO-Ab)和甲状腺球蛋白抗体(Tg-Ab)变化的随机对照研究。采用Revman5.4软件进行Meta分析。结果:共纳入6项随机对照试验(RCTs)研究,包含344例AIT患者。结果表明,与对照组相比,经过6个月维生素D治疗的AIT患者TPO-Ab及Tg-Ab滴度显著降低,无严重不良反应报道。结论:补充维生素D可以在短期内(约6个月)降低AIT患者的血清TPO-Ab和Tg-Ab滴度。

Objective: To evaluate the effects of vitamin D on the level of autoantibodies in patients with autoimmune thyroiditis(AIT) by Meta-analysis. Methods: The literature retrieval was conducted by using PubMed, Embase, The Cochrane Library, Chinese National Knowledge Infrastructure, Wanfang, and VIP Database to search for all studies evaluating thyroid peroxidase antibody(TPO-Ab) and thyroglobulin antibody(TG-Ab) changes in AIT patients treated with vitamin D. Meta-analysis was performed with software Revman5.4. Results: Six randomized controlled trials (RCTs) were included in this Meta-analysis representing a total of 344 patients with AIT. The results showed that TPO-Ab and Tg-Ab titer was significantly reduced in AIT patients treated with vitamin D supplementation for 6 months. No serious adverse effect was reported. Conclusion: Vitamin D supplementation can decrease serum TPO-Ab and Tg-Ab titer of patients with AIT in the short-term (about six months).

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