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巨噬细胞在卵巢生理和病理情况下作用的研究进展
作者:尹小瑞1  王莹东2  柳铮男1  谢静燕1  赵树立3 
单位:1. 南京医科大学附属南京医院 妇产科, 江苏 南京 210006;
2. 南京医科大学附属妇产医院 妇产科, 江苏 南京 210000;
3. 南京医科大学附属南京医院 中心实验室, 江苏 南京 210006
关键词:巨噬细胞 卵巢功能 妇科肿瘤 多囊卵巢综合征 子宫内膜异位症 综述 
分类号:R711.75
出版年·卷·期(页码):2021·40·第一期(119-124)
摘要:

巨噬细胞作为首位天然免疫细胞,在不同组织和环境中由多种不同亚型的细胞组成,它们不仅具有不同的吞噬杀菌、参与炎症反应、加工提呈抗原和免疫调节等多种功能,还能通过产生各种细胞因子来维持和参与体内多种生理病理活动的平衡。大量研究表明,巨噬细胞在卵巢的正常生理功能中发挥重要作用,参与卵泡的生长发育、黄体的生成及退化等;但在妇科肿瘤、多囊卵巢综合征及子宫内膜异位症等多种病理进程中,卵巢组织微环境成分的变化引起免疫平衡紊乱,最终导致巨噬细胞的极化和功能的改变。本文作者主要综述在卵巢生理与病理情况下巨噬细胞的极化和生物学功能相关方面的改变。

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