Objective: To study the correlation between bone mineral density (BMD) and serum calcium (Ca) phosphorus (P), vitamin D and bone metabolism index(BMI) in people over 40 years old in Wujiang District, Suzhou, Jiangsu. Methods: Multi-stage stratified random sampling method was used to select osteoporosis from March 2018 to July 2018 in Wujiang community. The BMD of lumbar spine (L1-4 and L2-4) and proximal femur (femoral neck, trochanter and total hip) were measured by dual energy X-ray absorptiometry (DXA). Results: The 217 subjects consisted of 82 males and 135 females, with an average age of (57.03 ±10.43) years. The difference of BMD level in different parts was statistically significant (P<0.01). Univariate analysis showed that sex, age, BMI, P, ALP, β-CTX, PINP were significantly correlated with BMD of all parts (P<0.01), 25 (OH) D3 was only significantly correlated with BMD of trochanter and total hip (P<0.05). After controlling gender, age and BMI, there was no significant correlation between Ca, 25 (OH) D3 and BMD of all parts, while serum P was only correlated with L1-4 and L2-4 at 0.05 level, the results showed statistically significant. The results of multiple stepwise regression analysis showed that being old and female were risk factors of BMD, BMI and BMD of all parts were positively correlated(all β>0,P<0.05). P was negatively correlated with BMD of femoral neck (β=-0.158), trochanter (β=-0.158) and total hip (β=-0.158), and all the results were statistically significant (P<0.05). Conclusion: The correlation among BMD, serology and bone metabolism indexes is statistically significant. Serum P was negatively correlated with BMD of Femoral neck, Trochanter and Total hip, and there was a negative correlation between PINP and BMD.
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