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妊娠期合并症/并发症对感染性产科出生人群短期影响的研究
作者:陈艳  陈超  和沁园  陈筱青  徐颖  韩国荣 
单位:南京中医药大学附属南京医院/南京市第二医院 新生儿科, 江苏 南京 210003
关键词:全出生人群 感染性疾病 合并症 高龄产妇 队列研究 
分类号:R759
出版年·卷·期(页码):2021·40·第一期(1-6)
摘要:

目的:通过产科全出生人群队列,回顾性分析本院产科分娩产妇妊娠期并发症/合并症对子代短期结局的影响。方法:将2019年4月至2020年3月在本院产科住院分娩的所有产妇纳入研究,收集母亲基本信息、妊娠期并发症/合并症、妊娠期药物治疗情况、分娩时的基本信息及新生儿结局。结果:研究期间共有1 431例产妇在本院分娩,1 457例新生儿出生。528例产妇被纳入妊娠期合并症并发症组。母亲妊娠期并发症/合并症组分娩的子代发生早产、低出生体质量、1 min Apgar评分≤7分和生后住院或死亡率显著升高。多因素Logistic回归分析发现,母亲年龄、梅毒、妊娠期糖尿病以及孕期肝功能异常需要降酶保肝治疗是增加子代出生后住院或死亡的独立危险因素。结论:本院产科分娩产妇妊娠期合并症/并发症发病率高,分娩子代中早产率高。孕妇高龄、合并妊娠期糖尿病、合并梅毒以及发生肝功能损伤,对子代出生后新生儿期发病和死亡的影响较大。

Objective: To analyze the short-term effect of maternal complication and/or co-morbidities on offspring in a retrospective birth-population based study in our obstetric department. Methods: All women delivered in our department from April 2019 to March 2020 were recruited in this study. Data of maternal basic information, pregnancy complications and/or co-morbidities, drugs used during pregnancy, basic information of delivery and outcomes of the neonates were obtained. Results: Totally 1 431 women and 1 457 newborns were included during the study. Pregnant complications and/or co-morbidities were associated with significantly higher rates of preterm birth, low birth weight, Apgar score ≤ 7 at 1 minute and hospitalization or death of the offspring. Maternal age, syphilis, gestational diabetes, and abnormal liver function during pregnancy which needed treatment were independent risk factors for increased hospitalization or death of offspring after birth by multivariate Logistic regression analysis. Conclusion: As a designated obstetric department of infectious diseases of Nanjing region, the incidence of complications and/or co-morbidities during pregnancy and the rate of preterm in offspring are high in our department. Old maternal age, combined with gestational diabetes, syphilis and liver injury had a great influence on the morbidity and mortality of newborns after birth.

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