目的：探讨川芎嗪对急性肺损伤的保护作用及其可能机制。方法：SD大鼠45只，随机分为对照组、模型组和川芎嗪干预组，每组15只。对照组大鼠仅予单纯气管插管，无其他操作。模型组大鼠予气管插管，通过机械通气制备急性肺损伤模型。川芎嗪干预组大鼠提前予雾化吸入川芎嗪再予机械通气。分别检测各组大鼠气道血浆微渗漏、肺组织细胞间紧密连接蛋白和肺内炎症因子的含量。结果：机械通气后，模型组大鼠较对照组气道血浆微渗漏显著增加，肺组织细胞间紧密连接破坏显著增加，肺组织内炎症因子释放明显增加，而予川芎嗪提前雾化吸入的川芎嗪干预组大鼠气道血浆微渗漏、肺组织细胞间紧密连接破坏以及炎症因子释放均减少。结论：川芎嗪对机械通气造成的急性肺损伤具有保护作用，可以改善气道炎症。

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