乳腺原发性鳞状细胞癌与三阴性乳腺癌临床特征、治疗及预后的比较-东南大学学报医学版

乳腺原发性鳞状细胞癌与三阴性乳腺癌临床特征、治疗及预后的比较

单位：1. 安庆市第一人民医院普外科, 安徽安庆 246004;
2. 广州医科大学附属第三医院乳腺外科, 广东广州 510150;
3. 安庆市第一人民医院病理科, 安徽安庆 246004

分类号：R737.9

出版年·卷·期（页码）：2020·39·第六期（787-792）

摘要：

目的：探讨乳腺原发性鳞状细胞癌（PPSCC）的临床特征、治疗及预后。方法：回顾分析作者所在两家医院2008年1月至2017年12月收治的15例乳腺PPSCC女性病例的资料，与同期收治的30例三阴性乳腺癌（TNBC）女性病例进行比较，并对研究对象进行随访，中位随访时间60个月。结果：15例乳腺PPSCC患者均接受了手术治疗：9例行乳腺癌根治术，其中3例术前行新辅助化疗；6例行保乳手术，其中2例术前行新辅助化疗。乳腺PPSCC患者与TNBC患者相比，年龄较长[（71.32±11.72）岁vs（57.24±10.31）岁，P=0.003）]，肿瘤直径较大[（43.00±28.47）mm vs（37.10±25.56）mm，P=0.032]，复发较早（3个月vs 18个月，P=0.014），3年无病生存率（DFS）及5年总生存率（OS）均较短（3年DFS：57.3%vs 67.5%，P=0.036；5年OS：45.1%vs 62.4%，P=0.040）。结论：乳腺PPSCC与TNBC相比预后更差。

Objective: To investigate the clinical features, treatment and prognosis of pure primary squamous cell carcinoma (PPSCC) of the breast. Methods: A retrospective analysis was performed on 15 female cases of PPSCC of the breast admitted between January 2008 and December 2017 to the First People's Hospital of Anqing City and the Third Affiliated Hospital of Guangzhou Medical University. These cases were compared to 30 female cases of triple-negative breast cancer(TNBC) admitted during the same period. Subjects were followed up, and the median follow-up time was 60 months. Results: All 15 PPSCC patients underwent surgery:9 underwent radical mastectomy, 3 of which underwent neoadjuvant chemotherapy before surgery; the other 6 underwent breast-conserving surgery, 2 of which underwent preoperative Neoadjuvant chemotherapy. Compared with the TNBC cases, patients with PPSCC of the breast were older in age[(71.32±11.72)years old vs (57.24±10.31)years old, P=0.003], had larger tumor diameters[(43.00±28.47)mm vs (37.10±25.56)mm,P=0.032], earlier relapses(3 months vs 18 months,P=0.014), worse disease-free survival(DFS)(3-year DFS:57.3% vs 67.5%, P=0.036) and overall survival(OS)(5-year OS:45.1% vs 62.4%,P=0.040), the differences were statistically significant(P<0.05). Conclusion: PPSCC of the breast has a worse prognosis than triple negative breast cancer.

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