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抑郁症影像遗传学研究进展
作者:侯卓良1  岳莹莹2  袁勇贵1 2 
单位:1. 东南大学 医学院, 江苏 南京 210009;
2. 东南大学附属中大医院 心理精神科, 江苏 南京 210009
关键词:抑郁症 影像遗传学 中间表型 综述 
分类号:R749.4;R445
出版年·卷·期(页码):2020·39·第五期(664-669)
摘要:

抑郁症是最常见的精神疾病之一,带来沉重的疾病负担,目前其发病机制尚不明确。自21世纪初,影像遗传学便开始用于抑郁症发病机制和诊疗方法的研究。早期研究集中于单核苷酸多态性与影像中间表型脑结构、功能之间的关系,后来逐渐扩展到多位点、多基因、通路基因和全基因组的研究,分析方法也从单变量逐步发展到多变量分析和机器学习,为抑郁症的发病机制提供证据。作者综述了抑郁症影像遗传学的研究进展,文章最后指出了抑郁症影像遗传学存在的不足之处,并对抑郁症影像遗传研究方法的未来发展方向进行展望。

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